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Tytuł:
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Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases.
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Autorzy:
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Gehl J; a Center for Experimental Drug and Gene Electrotransfer (C*EDGE), Department of Clinical Oncology and Palliative Care , Zealand University Hospital , Roskilde , Denmark.; b Department of Clinical Medicine, Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark.; c Department of Oncology Herlev and Gentofte Hospital , University of Copenhagen , Herlev , Denmark.
Sersa G; d Department of Experimental Oncology , Institute of Oncology Ljubljana , Ljubljana , Slovenia.
Matthiessen LW; c Department of Oncology Herlev and Gentofte Hospital , University of Copenhagen , Herlev , Denmark.
Muir T; e South Tees NHS Foundation Trust , James Cook University Hospital , Middlesbrough , UK.
Soden D; f Cork Cancer Research Centre , Western Gateway Building University College Cork , Cork , Ireland.
Occhini A; g Department of Otolaryngology Head and Neck Surgery , University of Pavia - IRCCS Policlinico San Matteo Foundation , Pavia , Italy.
Quaglino P; h Department of Medical Sciences , Dermatologic Clinic, University of Turin , Turin , Italy.
Curatolo P; i Department of Dermatology and Plastic Surgery , La Sapienza University , Roma , Italy.
Campana LG; j Department of Surgery Oncology and Gastroenterology (DISCOG) , University of Padova , Padova , Italy.; k Surgical Oncology Unit , Veneto Institute of Oncology IRCCS , Padova , Italy.
Kunte C; l Department of Dermatologic Surgery and Dermatology , Artemed Fachklinik München , Munich , Germany.; m Department of Dermatology and Allergology , Ludwig-Maximillian University , Munich , Germany.
Clover AJP; f Cork Cancer Research Centre , Western Gateway Building University College Cork , Cork , Ireland.; n Department of Plastic Surgery , Cork University Hospital , Cork , Ireland.
Bertino G; f Cork Cancer Research Centre , Western Gateway Building University College Cork , Cork , Ireland.
Farricha V; o Melanoma and Sarcoma Unit Department of Surgery , Portuguese Institute of Oncology, Rua Professor Lima Basto, Faculty of Medicine of Lisbon , Lisbon , Portugal.
Odili J; p Department of Plastic Surgery , St. George's University Hospitals NHS Foundation Trust , London , UK.
Dahlstrom K; q Department of Plastic Surgery , Herlev and Gentofte Hospital, University of Copenhagen , Copenhagen , Denmark.
Benazzo M; g Department of Otolaryngology Head and Neck Surgery , University of Pavia - IRCCS Policlinico San Matteo Foundation , Pavia , Italy.
Mir LM; r Vectorology and Anticancer Therapies , UMR 8203, CNRS, Univ. Paris-Sud, Gustave Roussy, Université Paris-Saclay , Villejuif , France.
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Źródło:
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Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2018 Jul; Vol. 57 (7), pp. 874-882. Date of Electronic Publication: 2018 Mar 25.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: London : Informa Healthcare
Original Publication: Stockholm, Sweden : Acta Oncologica, [1987-
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MeSH Terms:
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Practice Guidelines as Topic*
Electrochemotherapy/*standards
Electrochemotherapy/*trends
Skin Neoplasms/*drug therapy
Consensus ; Electrochemotherapy/methods ; Humans ; Melanoma/drug therapy ; Melanoma/pathology ; Melanoma/secondary ; Reference Standards ; Skin Neoplasms/pathology ; Skin Neoplasms/secondary ; Melanoma, Cutaneous Malignant
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Entry Date(s):
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Date Created: 20180327 Date Completed: 20181026 Latest Revision: 20231213
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Update Code:
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20240105
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DOI:
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10.1080/0284186X.2018.1454602
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PMID:
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29577784
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Electrochemotherapy is now in routine clinical use to treat cutaneous metastases of any histology, and is listed in national and international guidelines for cutaneous metastases and primary skin cancer. Electrochemotherapy is used by dermatologists, surgeons, and oncologists, and for different degrees and manifestations of metastases to skin and primary skin tumours not amenable to surgery. This treatment utilises electric pulses to permeabilize cell membranes in tumours, thus allowing a dramatic increase of the cytotoxicity of anti-cancer agents. Response rates, often after only one treatment, are very high across all tumour types. The most frequent indications are cutaneous metastases from malignant melanoma and breast cancer. In 2006, standard operating procedures (SOPs) were written for this novel technology, greatly facilitating introduction and dissemination of the therapy. Since then considerable experience has been obtained treating a wider range of tumour histologies and increasing size of tumours which was not originally thought possible. A pan-European expert panel drawn from a range of disciplines from dermatology, general surgery, head and neck surgery, plastic surgery, and oncology met to form a consensus opinion to update the SOPs based on the experience obtained. This paper contains these updated recommendations for indications for electrochemotherapy, pre-treatment information and evaluation, treatment choices, as well as follow-up.
