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Tytuł:
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A novel regulatory function of CDKN1A/p21 in TNFα-induced matrix metalloproteinase 9-dependent migration and invasion of triple-negative breast cancer cells.
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Autorzy:
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Zaremba-Czogalla M; Department of Gastrointestinal and General Surgery, Medical University of Wroclaw, Poland.
Hryniewicz-Jankowska A; Laboratory of Cytobiochemistry, Biotechnology Faculty, University of Wroclaw, Poland.
Tabola R; Department of Gastrointestinal and General Surgery, Medical University of Wroclaw, Poland.
Nienartowicz M; Department of Gastrointestinal and General Surgery, Medical University of Wroclaw, Poland.
Stach K; Department of Biochemistry, Medical University of Wroclaw, Poland.
Wierzbicki J; Department of Minimally Invasive Surgery and Proctology, Wroclaw Medical University, Wroclaw, Poland.
Cirocchi R; Department of General and Oncological Surgery, University of Perugia, Italy.
Ziolkowski P; Department of Pathology, Wroclaw Medical University, Wroclaw, Poland.
Tabaczar S; Laboratory of Cytobiochemistry, Biotechnology Faculty, University of Wroclaw, Poland.
Augoff K; Department of Gastrointestinal and General Surgery, Medical University of Wroclaw, Poland. Electronic address: .
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Źródło:
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Cellular signalling [Cell Signal] 2018 Jul; Vol. 47, pp. 27-36. Date of Electronic Publication: 2018 Mar 26.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Oxford : Elsevier Science Ltd
Original Publication: Oxford ; New York : Pergamon Press, 1988-
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MeSH Terms:
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Cyclin-Dependent Kinase Inhibitor p21/*metabolism
Matrix Metalloproteinase 9/*metabolism
Tumor Necrosis Factor-alpha/*pharmacology
Up-Regulation/*drug effects
Cell Line, Tumor ; Cell Movement/drug effects ; Cyclin-Dependent Kinase Inhibitor p21/antagonists & inhibitors ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Female ; Humans ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Phosphorylation/drug effects ; RNA Interference ; RNA, Small Interfering/metabolism ; Signal Transduction/drug effects ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology
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Contributed Indexing:
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Keywords: Breast cancer*; CDKN1A/p21((WAF1/CIP1/SDI1))*; Cell migration*; MMP9*; TNFα*
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Substance Nomenclature:
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0 (Cyclin-Dependent Kinase Inhibitor p21)
0 (RNA, Small Interfering)
0 (Tumor Necrosis Factor-alpha)
EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
EC 3.4.24.35 (Matrix Metalloproteinase 9)
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Entry Date(s):
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Date Created: 20180329 Date Completed: 20190917 Latest Revision: 20220330
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Update Code:
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20240105
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DOI:
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10.1016/j.cellsig.2018.03.010
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PMID:
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29588220
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Metastasis is the leading cause of mortality in patients with highly invasive cancers and, as such, is a major problem for medicine. It has been increasingly recognized that cancer-related inflammation plays an important role in promoting invasion and the metastatic process in which cell motility and upregulation of proteolytic enzymes are crucial events. TNFα is a proinflammatory cytokine known to stimulate synthesis of MMP9, a zinc- and calcium-dependent endopeptidase contributing to the regulation of ECM remodeling and cell signaling. However, the precise molecular mechanism of TNFα-induced MMP9 gene expression in cancers is still not fully understood. This study shows that TNFα-induced cell migration and invasion involve ERK1/2-dependent up-regulation of CDKN1A/p21 expression in highly aggressive breast cancer cells and that CDKN1A/p21 plays an important regulatory role in TNFα-induced MMP9 gene expression, indicating an unknown function of CDKN1A/p21 as a regulator of proteolytic activity in cancer cells.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Erratum in: Cell Signal. 2019 Jan;53:413. (PMID: 30446180)
