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Tytuł:
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Call for more transparency in manufacturers declarations on serum indices: On behalf of the Working Group for Preanalytical Phase (WG-PRE), European Federation of Clinical Chemistry and Laboratory Medicine (EFLM).
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Autorzy:
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von Meyer A; Institute for Laboratory Medicine, Kliniken Nordoberpfalz AG and Klinikum St. Marien, Weiden and Amberg, Germany. Electronic address: .
Cadamuro J; Department of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria.
Lippi G; Section of Clinical Biochemistry, University Hospital of Verona, Verona, Italy.
Simundic AM; Department of Medical Laboratory Diagnostics, University Hospital Sveti Duh, Zagreb, Croatia.
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Źródło:
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Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2018 Sep; Vol. 484, pp. 328-332. Date of Electronic Publication: 2018 Apr 02.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam, Elsevier.
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MeSH Terms:
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Artifacts*
Medical Laboratory Science*/methods
Medical Laboratory Science*/standards
Pre-Analytical Phase*
Bilirubin/*blood
Chemistry, Clinical/*methods
Chemistry, Clinical/*standards
Hemoglobins/*analysis
Lipids/*blood
Humans
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Contributed Indexing:
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Keywords: Hemolysis; Icterus; Interference; Lipemia; Preanalytical phase; Serum indices
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Substance Nomenclature:
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0 (Hemoglobins)
0 (Lipids)
RFM9X3LJ49 (Bilirubin)
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Entry Date(s):
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Date Created: 20180405 Date Completed: 20181112 Latest Revision: 20220408
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Update Code:
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20240104
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DOI:
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10.1016/j.cca.2018.03.043
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PMID:
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29617625
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The presence of interfering substances like free hemoglobin, bilirubin or lipids compromises sample quality and potentially affects laboratory analysis and test results. Recently, the use of serum indices for objectively assessing sample quality has become commonplace and many preanalytical platforms, as well as clinical chemistry and coagulation analyzers, are now equipped with this analytical feature. Nevertheless, some important drawbacks remain in this practice, mainly pertaining the measurement procedure, the approach for reporting interference data, the definition of objective thresholds of interference after which test results may be biased, and the lack of harmonized practices for describing how interference cut-offs have been identified. Therefore, this document aims to discuss these important caveats and propose some reliable solutions that may be adopted by manufacturers for increasing worldwide harmonization of serum indices.
(Copyright © 2018. Published by Elsevier B.V.)
