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Tytuł pozycji:

Adipose transcriptome analysis provides novel insights into molecular regulation of prolonged fasting in northern elephant seal pups.

Tytuł:
Adipose transcriptome analysis provides novel insights into molecular regulation of prolonged fasting in northern elephant seal pups.
Autorzy:
Martinez B; Department of Molecular & Cellular Biology, University of California, Merced, California.; Department of Medicine, St. George's University School of Medicine, St. George, Grenada.; Department of Anatomy, University of Otago , Dunedin , New Zealand.; Department of Physics and Engineering, Los Alamos National Laboratory , Los Alamos, New Mexico.
Khudyakov J; Department of Biological Sciences, University of the Pacific , Stockton, California.
Rutherford K; Department of Anatomy, University of Otago , Dunedin , New Zealand.
Crocker DE; Department of Biology, Sonoma State University , Rohnert Park, California.
Gemmell N; Department of Anatomy, University of Otago , Dunedin , New Zealand.
Ortiz RM; Department of Molecular & Cellular Biology, University of California, Merced, California.
Źródło:
Physiological genomics [Physiol Genomics] 2018 Jul 01; Vol. 50 (7), pp. 495-503. Date of Electronic Publication: 2018 Apr 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Język:
English
Imprint Name(s):
Original Publication: Bethesda, MD : American Physiological Society, c1999-
MeSH Terms:
Gene Expression Profiling*
Transcriptome*
Adipose Tissue/*metabolism
Seals, Earless/*genetics
Adiposity/genetics ; Animals ; Carbohydrate Metabolism/genetics ; Energy Metabolism/genetics ; Fasting ; Lipid Metabolism/genetics ; Proteome/genetics ; Seals, Earless/metabolism ; Weaning
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Contributed Indexing:
Keywords: adipose; de novo assembly; extracellular matrix; fasting; transcriptome
Substance Nomenclature:
0 (Proteome)
Entry Date(s):
Date Created: 20180407 Date Completed: 20190826 Latest Revision: 20190826
Update Code:
20240104
PubMed Central ID:
PMC6087879
DOI:
10.1152/physiolgenomics.00002.2018
PMID:
29625017
Czasopismo naukowe
The physiological and cellular adaptations to extreme fasting in northern elephant seals ( Mirounga angustirostris, NES) are remarkable and may help to elucidate endocrine mechanisms that regulate lipid metabolism and energy homeostasis in mammals. Recent studies have highlighted the importance of thyroid hormones in the maintenance of a lipid-based metabolism during prolonged fasting in weaned NES pups. To identify additional molecular regulators of fasting, we used a transcriptomics approach to examine changes in global gene expression profiles before and after 6-8 wk of fasting in weaned NES pups. We produced a de novo assembly and identified 98 unique protein-coding genes that were differentially expressed between early and late fasting. Most of the downregulated genes were associated with lipid, carbohydrate, and protein metabolism. A number of downregulated genes were also associated with maintenance of the extracellular matrix, consistent with tissue remodeling during weight loss and the multifunctional nature of blubber tissue, which plays both metabolic and structural roles in marine mammals. Using this data set, we predict potential mechanisms by which NES pups sustain metabolism and regulate adipose stores throughout the fast, and provide a valuable resource for additional studies of extreme metabolic adaptations in mammals.

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