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Tytuł pozycji:

In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons.

Tytuł :
In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons.
Autorzy :
Alsaad HA; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, USA.
DeKorver NW; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, USA.
Mao Z; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, USA.
Dravid SM; Department of Pharmacology, Creighton University, Omaha, NE, USA.
Arikkath J; Department of Developmental Neuroscience, Monroe Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA.
Monaghan DT; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, USA. .
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Źródło :
Neurochemical research [Neurochem Res] 2019 Jan; Vol. 44 (1), pp. 61-77. Date of Electronic Publication: 2018 Apr 12.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: 1999- : New York, NY : Kluwer Academic/Plenum Publishers
Original Publication: New York, Plenum Press
MeSH Terms :
Interneurons/*metabolism
Neuroglia/*metabolism
RNA, Messenger/*biosynthesis
Receptors, N-Methyl-D-Aspartate/*biosynthesis
Telencephalon/*metabolism
Animals ; Gene Expression ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Protein Subunits/biosynthesis ; Protein Subunits/genetics ; RNA, Messenger/genetics ; Receptors, N-Methyl-D-Aspartate/genetics
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Grant Information :
P30 GM110768 United States GM NIGMS NIH HHS; MH60252 National Institutes of Health (US); R01 MH060252 United States MH NIMH NIH HHS; GM110768 National Institutes of Health (US); R21 NS104705 United States NS NINDS NIH HHS
Contributed Indexing :
Keywords: Astrocyte; Cortex; GluN2C; GluN2D; Hippocampus; L-glutamate; N-methyl-D-aspartate receptor; mRNA
Substance Nomenclature :
0 (NR2C NMDA receptor)
0 (NR2D NMDA receptor)
0 (Protein Subunits)
0 (RNA, Messenger)
0 (Receptors, N-Methyl-D-Aspartate)
Entry Date(s) :
Date Created: 20180414 Date Completed: 20190314 Latest Revision: 20200225
Update Code :
20210914
PubMed Central ID :
PMC6349034
DOI :
10.1007/s11064-018-2526-7
PMID :
29651654
Czasopismo naukowe
N-methyl-D-aspartate receptors (NMDARs) are widely distributed in the brain with high concentrations in the telencephalon where they modulate synaptic plasticity, working memory, and other functions. While the actions of the predominate GluN2 NMDAR subunits, GluN2A and GluN2B are relatively well understood, the function of GluN2C and GluN2D subunits in the telencephalon is largely unknown. To better understand the possible role of GluN2C subunits, we used fluorescence in situ hybridization (FISH) together with multiple cell markers to define the distribution and type of cells expressing GluN2C mRNA. Using a GluN2C-KO mouse as a negative control, GluN2C mRNA expression was only found in non-neuronal cells (NeuN-negative cells) in the hippocampus, striatum, amygdala, and cerebral cortex. For these regions, a significant fraction of GFAP-positive cells also expressed GluN2C mRNA. Overall, for the telencephalon, the globus pallidus and olfactory bulb were the only regions where GluN2C was expressed in neurons. In contrast to GluN2C, GluN2D subunit mRNA colocalized with neuronal and not astrocyte markers or GluN2C mRNA in the telencephalon (except for the globus pallidus). GluN2C mRNA did, however, colocalize with GluN2D in the thalamus where neuronal GluN2C expression is found. These findings strongly suggest that GluN2C has a very distinct function in the telencephalon compared to its role in other brain regions and compared to other GluN2-containing NMDARs. NMDARs containing GluN2C may have a specific role in regulating L-glutamate or D-serine release from astrocytes in response to L-glutamate spillover from synaptic activity.

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