ACMT Position Statement: Alternative or Contingency Countermeasures for Acetylcholinesterase Inhibiting Agents.

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Tytuł:: ACMT Position Statement: Alternative or Contingency Countermeasures for Acetylcholinesterase Inhibiting Agents.
Autorzy:: Stolbach A; Johns Hopkins University, Baltimore, MD, USA. .
Bebarta V; University of Colorado School of Medicine, Denver, CO, USA.
Beuhler M; Carolinas Poison Center, Charlotte, NC, USA.
Carstairs S; University of California, San Diego, CA, USA.
Nelson L; Rutgers New Jersey Medical School, Newark, NJ, USA.
Wahl M; Illinois Poison Center, Chicago, IL, USA.
Wax PM; University of Texas Southwestern Medical School, Dallas, TX, USA.
McKay C; University of Connecticut School of Medicine, Farmington, CT, USA.
Źródło:: Journal of medical toxicology : official journal of the American College of Medical Toxicology [J Med Toxicol] 2018 Sep; Vol. 14 (3), pp. 261-263. Date of Electronic Publication: 2018 Apr 17.
Typ publikacji:: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Język:: English
Imprint Name(s):: Publication: 2010- : New York : Springer
Original Publication: Philadelphia, Pa. : University of Pennsylvania Press, c2005-
MeSH Terms:: Societies, Medical*
Toxicology*
Cholinesterase Inhibitors/*poisoning
Chemical Warfare Agents ; Cholinesterase Reactivators/therapeutic use ; Drug Storage ; Humans ; Organophosphate Poisoning/drug therapy ; Poisoning/therapy ; United States
References:: Am J Emerg Med. 2010 Feb;28(2):143-50. (PMID: 20159382)
Hum Exp Toxicol. 2009 Nov;28(11):715-20. (PMID: 19850654)
Environ Toxicol Pharmacol. 2009 Mar;27(2):206-11. (PMID: 21783941)
J Asthma Allergy. 2012;5:39-49. (PMID: 22952410)
Ann Emerg Med. 2012 Oct;60(4):424-30. (PMID: 22738685)
Emerg Med Clin North Am. 2015 Feb;33(1):213-32. (PMID: 25455670)
J Med Toxicol. 2015 Mar;11(1):144-6. (PMID: 25711999)
Epilepsy Res. 2016 May;122:47-55. (PMID: 26922313)
Acad Emerg Med. 2004 Apr;11(4):329-34. (PMID: 15064203)
Acad Emerg Med. 2003 Mar;10(3):290. (PMID: 12615600)
Grant Information:: United States Department of Homeland Security ACMT/DHS Contract number HSHQDC-14-R-00102. International United States Department of Homeland Security ACMT/DHS Contract number HSHQDC-14-R-00102.
Contributed Indexing:: Keywords: Acetylcholinesterase inhibitors; Atropine; Countermeasures; Expiration date; Pralidoxime
Substance Nomenclature:: 0 (Chemical Warfare Agents)
0 (Cholinesterase Inhibitors)
0 (Cholinesterase Reactivators)
Entry Date(s):: Date Created: 20180419 Date Completed: 20190923 Latest Revision: 20190923
Update Code:: 20240104
PubMed Central ID:: PMC6097966
DOI:: 10.1007/s13181-018-0658-4
PMID:: 29667118
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First responders and health care providers must prepare to provide care for patients poisoned by acetylcholinesterase (AchE) inhibitor chemical warfare agents or pesticides. However, pre-deployed medical countermeasures (MCMs) may not be sufficient due to production and delivery interruption, rapid depletion of contents during a response, expiration of MCM components, or lack of local availability of approved MCMs. To augment supplies of community-based and forward-deployed nerve agent countermeasures, the American College of Medical Toxicology (ACMT) supports several strategies: (1) The use of expired atropine, diazepam, and pralidoxime auto-injectors and vials if non-expired drugs are unavailable; and (2) Investigation, development, and identification of alternative countermeasures-commonly stocked drugs that are not approved for nerve agent poisoning but are in the same therapeutic class as approved drugs.

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