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Tytuł pozycji:

Mice lacking galectin-3 (Lgals3) function have decreased home cage movement.

Tytuł :
Mice lacking galectin-3 (Lgals3) function have decreased home cage movement.
Autorzy :
Chaudoin TR; Division of Geriatrics, Department of Internal Medicine, University of Nebraska Medical Center, 3028 Durham Research Center II, Omaha, NE, 68198-5039, USA.
Bonasera SJ; Division of Geriatrics, Department of Internal Medicine, University of Nebraska Medical Center, 3028 Durham Research Center II, Omaha, NE, 68198-5039, USA. .
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Źródło :
BMC neuroscience [BMC Neurosci] 2018 May 02; Vol. 19 (1), pp. 27. Date of Electronic Publication: 2018 May 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Język :
English
Imprint Name(s) :
Original Publication: London: BioMed Central, [2000-
MeSH Terms :
Behavior, Animal/*physiology
Circadian Rhythm/*physiology
Galectin 3/*deficiency
Locomotion/*genetics
Animals ; Mice, Inbred C57BL ; Mice, Knockout ; Recognition, Psychology/physiology
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Grant Information :
R01 AG031158 United States AG NIA NIH HHS
Contributed Indexing :
Keywords: Circadian rhythm*; Galectin-3*; Ingestive behavior*; Lgals3*; Locomotor behavior*
Substance Nomenclature :
0 (Galectin 3)
0 (Lgals3 protein, mouse)
Entry Date(s) :
Date Created: 20180503 Date Completed: 20190516 Latest Revision: 20191210
Update Code :
20210623
PubMed Central ID :
PMC5930520
DOI :
10.1186/s12868-018-0428-x
PMID :
29716523
Czasopismo naukowe
Background: Galectins are a large family of proteins evolved to recognize specific carbohydrate moieties. Given the importance of pattern recognition processes for multiple biological tasks, including CNS development and immune recognition, we examined the home cage behavioral phenotype of mice lacking galectin-3 (Lgals3) function. Using a sophisticated monitoring apparatus capable of examining feeding, drinking, and movement at millisecond temporal and 0.5 cm spatial resolutions, we observed daily behavioral patterns from 10 wildtype male C57BL/6J and 10 Lgals3 constitutive knockout (Lgals3 -/- ; both cohorts aged 2-3 months) mice over 17 consecutive days. We performed a second behavioral assessment of this cohort at age 6-7 months.
Results: At both ages, Lgals3 -/- mice demonstrated less movement compared to wildtype controls. Both forward locomotion and movement-in-place behaviors were decreased in Lgals3 -/- mice, due to decreased bout numbers, initiation rates, and durations. We additionally noted perturbation of behavioral circadian rhythms in Lgals3 -/- mice, with mice at both ages demonstrating greater variability in day-to-day performance of feeding, drinking, and movement (as assessed by Lomb-Scargle analysis) compared to wildtype.
Conclusion: Carbohydrate recognition tasks performed by Lgals3 may be required for appropriate development of CNS structures involved in the generation and control of locomotor behavior.
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