[The role of single nucleotide polymorphisms in GIPR gene in the changes of secretion in hormones and adipokines in patients with obesity with type 2 diabetes].

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Tytuł:: [The role of single nucleotide polymorphisms in GIPR gene in the changes of secretion in hormones and adipokines in patients with obesity with type 2 diabetes].
Autorzy:: Skuratovskaia DA; Immanuel Kant Baltic Federal University, Kaliningrad, Russia.
Vulf MA; Immanuel Kant Baltic Federal University, Kaliningrad, Russia.
Kirienkova EV; Immanuel Kant Baltic Federal University, Kaliningrad, Russia.
Mironyuk NI; Regional Clinical Hospital of the Kaliningrad Region, Kaliningrad, Russia.
Zatolokin PA; Immanuel Kant Baltic Federal University, Kaliningrad, Russia; Regional Clinical Hospital of the Kaliningrad Region, Kaliningrad, Russia.
Litvinova LS; Immanuel Kant Baltic Federal University, Kaliningrad, Russia.
Transliterated Title:: Rol' odnonukleotidnykh polimorfizmov gena GIPR v reguliatsii sekretsii gormonov i adipokinov pri ozhirenii, oslozhnennom sakharnym diabetom 2 tipa.
Źródło:: Biomeditsinskaia khimiia [Biomed Khim] 2018 Mar; Vol. 64 (2), pp. 208-216.
Typ publikacji:: Journal Article
Język:: Russian
Imprint Name(s):: Original Publication: Moskva : Rossiĭskai︠a︡ akademii︠a︡ medit︠s︡inskikh nauk, 2003-
MeSH Terms:: Polymorphism, Single Nucleotide*
Adipokines/*metabolism
Diabetes Mellitus, Type 2/*metabolism
Obesity/*metabolism
Receptors, Gastrointestinal Hormone/*genetics
Humans ; Russia
Contributed Indexing:: Keywords: adipokines; gene expression; glucosedependent insulinotropic polypeptide; hormones; incretins; polymorphism
Local Abstract: [Publisher, Russian] Issledovany vzaimosviazi polimorfizmov rs2302382, rs8111428 i Glu354Gln (rs1800437) gena retseptora gliukozozavisimogo insulinotropnogo polipeptida GIP (GIPR) s plazmennymi urovniami mediatorov, uchastvuiushchikh v reguliatsii uglevodnogo obmena u bol'nykh ozhireniem s SD 2 tipa (natoshchak i posle testovogo zavtraka). Ustanovlen vklad polimorfnykh variantov rs2302382, rs8111428 gena GIPR v formirovanie SD 2 tipa u lits, otnosiashchikhsia k vostochnoslavianskoĭ populiatsii Rossii. Okharakterizovano neravnovesnoe stseplenie mezhdu polimorfizmami rs2302382 i rs8111428 v gene GIPR. Ustanovleno, chto snizhenie urovnia ékspressii gena GIPR v zhirovoĭ tkani bryzheĭki tonkogo kishechnika u nositeleĭ genotipa SS rs2302382 i AA rs8111428 assotsiirovano s povysheniem plazmennogo urovnia leptina, togda kak pri normal'noĭ ego ékspressii registriruetsia rost plazmennogo soderzhaniia insulina, GIP (u lits s genotipom SA polimorfizma rs2302382 i AG polimorfizma rs8111428), rezistina i grelina (u lits s genotipom SA polimorfizma rs2302382). My predpolagaem stimuliruiushchiĭ éffekt GIP na sekretsiiu rezistina, leptina i grelina posredstvom uvelicheniia produktsii insulina u bol'nykh ozhireniem s SD 2 tipa.
Substance Nomenclature:: 0 (Adipokines)
0 (Receptors, Gastrointestinal Hormone)
D6H00MV7K8 (gastric inhibitory polypeptide receptor)
Entry Date(s):: Date Created: 20180504 Date Completed: 20190513 Latest Revision: 20190513
Update Code:: 20240104
DOI:: 10.18097/PBMC20186402208
PMID:: 29723152
: Czasopismo naukowe

The relationship between the rs2302382, rs8111428 and Glu354Gln (rs1800437) polymorphisms in GIPR (glucosedependent insulinotropic polypeptide receptor) gene and plasma levels of mediators involved in the regulation of carbohydrate metabolism in obese patients with type 2 diabetes (before and after a test breakfast) was investigated. The contribution of polymorphic variants of rs2302382, rs8111428 in GIPR gene in the predisposition to type 2 diabetes in individuals belonging to the Slavic population of Russia was found. Polymorphisms rs2302382 and rs8111428 in the GIPR gene were characterized by the nonequilibrium cohesion. The decrease in the level of expression of the GIPR gene in adipose tissue of the small intestine mesentery in the carriers of the CC genotype rs2302382 and AA rs8111428 was associated with the increase in the plasma leptin level, whereas during normal expression, the plasma content of insulin, and GIP (in persons with the genotype of the polymorphism rs2302382 and AG polymorphism rs8111428), resistin and ghrelin (in individuals with the genotype of the polymorphism rs2302382) increased. We propose the stimulating effect of GIP on the secretion of resistin, leptin and ghrelin, with an increase in insulin production in obese patients with type 2 diabetes.

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