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Tytuł pozycji:

Evidence for secretion of vasoactive intestinal peptide by tumours of pancreas, adrenal medulla, thyroid and lung: support for the unifying APUD concept.

Tytuł:
Evidence for secretion of vasoactive intestinal peptide by tumours of pancreas, adrenal medulla, thyroid and lung: support for the unifying APUD concept.
Autorzy:
Said SI
Źródło:
Clinical endocrinology [Clin Endocrinol (Oxf)] 1976; Vol. 5 Suppl, pp. 201S-204S.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, P.H.S.
Język:
English
Imprint Name(s):
Publication: <2003->: Oxford : Blackwell Publishing
Original Publication: Oxford, Blackwell Scientific Publications.
MeSH Terms:
APUD Cells*
Adrenal Gland Neoplasms/*metabolism
Adrenal Medulla/*metabolism
Gastrointestinal Hormones/*metabolism
Lung Neoplasms/*metabolism
Pancreatic Neoplasms/*metabolism
Thyroid Neoplasms/*metabolism
Vasoactive Intestinal Peptide/*metabolism
Adrenal Gland Neoplasms/complications ; Adrenal Gland Neoplasms/pathology ; Adrenal Medulla/pathology ; Diarrhea/etiology ; Humans ; Lung Neoplasms/complications ; Lung Neoplasms/pathology ; Pancreatic Neoplasms/complications ; Pancreatic Neoplasms/pathology ; Radioimmunoassay ; Thyroid Neoplasms/complications ; Thyroid Neoplasms/pathology ; Vasoactive Intestinal Peptide/blood
Substance Nomenclature:
0 (Gastrointestinal Hormones)
37221-79-7 (Vasoactive Intestinal Peptide)
Entry Date(s):
Date Created: 19760101 Date Completed: 19781229 Latest Revision: 20190813
Update Code:
20240104
DOI:
10.1111/j.1365-2265.1976.tb03828.x
PMID:
29733
Czasopismo naukowe
Levels of vasoactive intestinal polypeptide (VIP) were measured by radioimmunoassay in plasma or tissue from thirty-five patients with watery diarrhoea, and in plasma of twenty-five normal controls. Plasma levels were between 0.6 and 11.0 ng/ml in thirty-one of the thirty-three patients in whom it was measured and too low to measure (less than 200 pg/ml) in the other two. Peptide levels were less than 200 pg/ml in twenty-three of the controls, but higher in the remaining two. All tissues from patients were "rich" in VIP (10 ng to 35 microgram per g). The aetiologic diagnoses included pancreatic islet-cell adenoma or adenocarcinoma, islet-cell hyperplasia, bronchogenic carcinoma, pheochromocytoma, ganglioneuroblastoma, medullary thyroid carcinoma, and retroperitoneal histiocytoma. The findings support the conclusions that: (1) VIP is a likely mediator of the water-diarrhoea syndrome; (2) the syndrome may result from a variety of tumours; (3) this or a related peptide hormone may be secreted by these tumours; and (4) these tumours may have a common embryonic origin.

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