Molecular biomarkers of Alzheimer's disease: progress and prospects.

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Tytuł:: Molecular biomarkers of Alzheimer's disease: progress and prospects.
Autorzy:: Lashley T; Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.
Schott JM; Dementia Research Centre, UCL Institute of Neurology, London WC1N 3BG, UK.
Weston P; Dementia Research Centre, UCL Institute of Neurology, London WC1N 3BG, UK.
Murray CE; Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.
Wellington H; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.; UK Dementia Research Institute, London WC1N 3BG, UK.
Keshavan A; Dementia Research Centre, UCL Institute of Neurology, London WC1N 3BG, UK.
Foti SC; Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.
Foiani M; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.; UK Dementia Research Institute, London WC1N 3BG, UK.
Toombs J; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.; UK Dementia Research Institute, London WC1N 3BG, UK.
Rohrer JD; Dementia Research Centre, UCL Institute of Neurology, London WC1N 3BG, UK.
Heslegrave A; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.; UK Dementia Research Institute, London WC1N 3BG, UK.
Zetterberg H; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK .; UK Dementia Research Institute, London WC1N 3BG, UK.; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal S-431 80, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal S-431 80, Sweden.
Źródło:: Disease models & mechanisms [Dis Model Mech] 2018 May 08; Vol. 11 (5). Date of Electronic Publication: 2018 May 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
Język:: English
Imprint Name(s):: Original Publication: Cambridge : Company of Biologists Ltd., c2008-
MeSH Terms:: Alzheimer Disease/*diagnosis
Biomarkers/*metabolism
Alzheimer Disease/blood ; Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/pathology ; Animals ; Axons/pathology ; Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; Humans ; Nerve Degeneration/pathology ; Neuroglia/metabolism ; Neuroglia/pathology ; Synapses/metabolism ; Synapses/pathology
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Grant Information:: United Kingdom WT_ Wellcome Trust; MR/M008525/1 United Kingdom MRC_ Medical Research Council
Contributed Indexing:: Keywords: Alzheimer's disease; Amyloid; Biomarkers; Blood; Cerebrospinal fluid; Neurofilament; Neurogranin; Plasma; Serum; Tau
Substance Nomenclature:: 0 (Biomarkers)
Entry Date(s):: Date Created: 20180510 Date Completed: 20181109 Latest Revision: 20220129
Update Code:: 20240104
PubMed Central ID:: PMC5992610
DOI:: 10.1242/dmm.031781
PMID:: 29739861
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The neurodegenerative disorder Alzheimer's disease is characterised by the formation of β-amyloid plaques and neurofibrillary tangles in the brain parenchyma, which cause synapse and neuronal loss. This leads to clinical symptoms, such as progressive memory deficits. Clinically, these pathological changes can be detected in the cerebrospinal fluid and with brain imaging, although reliable blood tests for plaque and tangle pathologies remain to be developed. Plaques and tangles often co-exist with other brain pathologies, including aggregates of transactive response DNA-binding protein 43 and Lewy bodies, but the extent to which these contribute to the severity of Alzheimer's disease is currently unknown. In this 'At a glance' article and poster, we summarise the molecular biomarkers that are being developed to detect Alzheimer's disease and its related pathologies. We also highlight the biomarkers that are currently in clinical use and include a critical appraisal of the challenges associated with applying these biomarkers for diagnostic and prognostic purposes of Alzheimer's disease and related neurodegenerative disorders, also in their prodromal clinical phases.
Competing Interests: Competing interestsThe authors declare no competing or financial interests.
(© 2018. Published by The Company of Biologists Ltd.)

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