Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons.

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Abstrakt

Tytuł:: Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons.
Autorzy:: Telezhkin V; School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK. .; School of Biosciences, Cardiff University, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK. .; Department of Neuroscience, Physiology and Pharmacology, London University College, London, UK. .
Straccia M; Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, August Pi Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
Yarova P; School of Biosciences, Cardiff University, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK.
Pardo M; Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, August Pi Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
Yung S; School of Biosciences, Cardiff University, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK.
Vinh NN; School of Biosciences, Cardiff University, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK.
Hancock JM; School of Physiology and Pharmacology, University of Bristol, Bristol, UK.
Barriga GG; Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, August Pi Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
Brown DA; Department of Neuroscience, Physiology and Pharmacology, London University College, London, UK.
Rosser AE; School of Biosciences, Cardiff University, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK.; Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Hadyn Ellis Building, Cardiff, CF24 4HQ, UK.
Brown JT; Hatherly Laboratory, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK.
Canals JM; Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, August Pi Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
Randall AD; School of Physiology and Pharmacology, University of Bristol, Bristol, UK.; Hatherly Laboratory, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK.
Allen ND; School of Biosciences, Cardiff University, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK.
Kemp PJ; School of Biosciences, Cardiff University, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK.
Źródło:: Pflugers Archiv : European journal of physiology [Pflugers Arch] 2018 Sep; Vol. 470 (9), pp. 1359-1376. Date of Electronic Publication: 2018 May 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Berlin, New York, Springer.
MeSH Terms:: Induced Pluripotent Stem Cells/*metabolism
KCNQ1 Potassium Channel/*metabolism
Neurons/*metabolism
Up-Regulation/*physiology
Animals ; Cell Differentiation/physiology ; Cells, Cultured ; Humans ; Membrane Potentials/physiology ; Mice ; RNA, Messenger/metabolism
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Grant Information:: MR/L010305/1 United Kingdom MRC_ Medical Research Council; MR/L023784/1 United Kingdom MRC_ Medical Research Council; MR/L023784/2 United Kingdom MRC_ Medical Research Council; MR/M02475X/1 United Kingdom MRC_ Medical Research Council
Contributed Indexing:: Keywords: Human-induced pluripotent stem cells; KCNQ; Kv7; Patch-clamp; Striatum
Substance Nomenclature:: 0 (KCNQ1 Potassium Channel)
0 (KCNQ1 protein, human)
0 (RNA, Messenger)
Entry Date(s):: Date Created: 20180526 Date Completed: 20190830 Latest Revision: 20210109
Update Code:: 20240105
PubMed Central ID:: PMC6096767
DOI:: 10.1007/s00424-018-2155-7
PMID:: 29797067
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Kv7 channels determine the resting membrane potential of neurons and regulate their excitability. Even though dysfunction of Kv7 channels has been linked to several debilitating childhood neuronal disorders, the ontogeny of the constituent genes, which encode Kv7 channels (KNCQ), and expression of their subunits have been largely unexplored. Here, we show that developmentally regulated expression of specific KCNQ mRNA and Kv7 channel subunits in mouse and human striatum is crucial to the functional maturation of mouse striatal neurons and human-induced pluripotent stem cell-derived neurons. This demonstrates their pivotal role in normal development and maturation, the knowledge of which can now be harnessed to synchronise and accelerate neuronal differentiation of stem cell-derived neurons, enhancing their utility for disease modelling and drug discovery.

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