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Tytuł pozycji:

MTHFR 677C → T genotype modulates the effect of a 5-year supplementation with B-vitamins on homocysteine concentration: The SU.FOL.OM3 randomized controlled trial.

Tytuł :
MTHFR 677C → T genotype modulates the effect of a 5-year supplementation with B-vitamins on homocysteine concentration: The SU.FOL.OM3 randomized controlled trial.
Autorzy :
Fezeu LK; Université Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre de Recherche en Epidémiologie et Statistiques, Inserm (U1153), Inra (U1125), Cnam, COMUE Sorbonne Paris Cité, Bobigny, France.
Ducros V; Département de Biochimie Pharmacologie et Toxicologie, UM Biochimie Nutritionnelle et Hormonale, Institut de Biologie et Pathologie, Centre Hospitalier Universitaire, Grenoble, France.
Guéant JL; Inserm U724, Pathologies Cellulaire et Moléculaire en Nutrition, Faculté de Médecine, Université Henry Poincaré, Vandoeuvre lès Nancy, France.
Guilland JC; LPPCE, Faculté de Médecine, Université de Bourgogne, Dijon, France.
Andreeva VA; Université Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre de Recherche en Epidémiologie et Statistiques, Inserm (U1153), Inra (U1125), Cnam, COMUE Sorbonne Paris Cité, Bobigny, France.
Hercberg S; Université Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre de Recherche en Epidémiologie et Statistiques, Inserm (U1153), Inra (U1125), Cnam, COMUE Sorbonne Paris Cité, Bobigny, France.; Département de Santé Publique, Hôpital Avicenne, Bobigny, France.
Galan P; Université Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre de Recherche en Epidémiologie et Statistiques, Inserm (U1153), Inra (U1125), Cnam, COMUE Sorbonne Paris Cité, Bobigny, France.
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Źródło :
PloS one [PLoS One] 2018 May 29; Vol. 13 (5), pp. e0193352. Date of Electronic Publication: 2018 May 29 (Print Publication: 2018).
Typ publikacji :
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms :
Dietary Supplements*
Polymorphism, Genetic*
Cardiovascular Diseases/*drug therapy
Homocysteine/*blood
Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
Vitamin B Complex/*administration & dosage
Cardiovascular Diseases/genetics ; Cardiovascular Diseases/physiopathology ; Double-Blind Method ; Female ; Genotype ; Humans ; Male ; Middle Aged
References :
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Substance Nomenclature :
0LVT1QZ0BA (Homocysteine)
12001-76-2 (Vitamin B Complex)
EC 1.5.1.20 (MTHFR protein, human)
EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
Entry Date(s) :
Date Created: 20180530 Date Completed: 20180730 Latest Revision: 20181114
Update Code :
20210301
PubMed Central ID :
PMC5973566
DOI :
10.1371/journal.pone.0193352
PMID :
29813097
Czasopismo naukowe
Aims: To study how MTHFR 677C→T genotype modulates the effect of supplementation with B-vitamins on total homocysteine (tHcy) and B-vitamin concentrations.
Methods: 2381 patients with a personal history of cardiovascular disease were randomly assigned to one of four groups: 1) B-vitamins alone (560 μg of 5-methyl-THF, 3 mg of vitamin B6 and 20 μg of vitamin B12), 2) n-3 fatty acids alone (600 mg of EPA and DHA in a 2:1 ratio), 3) B-vitamins and n-3 fatty acids, and 4) placebo. Participants were followed up for 4.7 years. At baseline and annually thereafter, biological parameters were assessed. Multivariate and linear mixed models were fit to study the interaction between B-vitamins and MTHFR genotype.
Results: Among supplemented participants, concentrations of all three B-vitamins increased during the first year (all p<0.0001) across MTHFR genotype categories. tHcy decreased by 26.3% during the first year (p<0.0001), then steadily increased throughout the 5 years (ptrend<0.001). However, at the end of follow-up, that increase was smaller among TT than among CT or CC subjects (pinteraction<0.02). At baseline, the difference in tHcy concentrations between TT homozygous and CC homozygous subjects was 2.33 μmol/l (p<0.001). After 5 years, that difference was reduced to 1.06 μmol/l and remained statistically significant (p<0.001).
Conclusion: Participants with the TT genotype exhibited a lower 5-year decrease in tHcy concentrations following a B-vitamin supplementation than did participants with the CC or CT genotype.
Clinical Trial Registration: Current Controlled Trials # ISRCTN41926726.
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