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Tytuł:
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Immunoglobulin and T cell receptor genes in Chinese crocodile lizard Shinisaurus crocodilurus.
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Autorzy:
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Gambón-Deza F; Immunology Unit, Hospital of Meixoiero, Vigo, Spain. Electronic address: .
Olivieri DN; School of Computer Science, University of Vigo, Ourense 32004, Spain. Electronic address: .
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Źródło:
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Molecular immunology [Mol Immunol] 2018 Sep; Vol. 101, pp. 160-166. Date of Electronic Publication: 2018 Jun 22.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Oxford, Elmsford, N. Y., Pergamon Press.
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MeSH Terms:
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Genes, Immunoglobulin*
Genes, T-Cell Receptor*
Lizards/*genetics
Amino Acid Sequence ; Animals ; Exons/genetics ; Phylogeny
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Contributed Indexing:
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Keywords: Immunoglobulin genes; Immunologic Repertoire; Squamata evolution; T cell receptor
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Entry Date(s):
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Date Created: 20180626 Date Completed: 20190325 Latest Revision: 20190325
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Update Code:
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20240104
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DOI:
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10.1016/j.molimm.2018.06.263
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PMID:
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29940409
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Squamata are reptiles that diverged from mammals 300 million years ago. During this period, the immunoglobulin (IG) and T lymphocyte receptor (TCR) genes evolved parallel to mammals. However, unlike mammals whose IG/TCR locus has retained a constant structure throughout evolution, Squamata have witnessed duplications, losses, and/or gains in the domains of their immunoglobulin genes. The recent genome sequencing of Shinisaurus crocodilurus, a representative species of the oldest reptiles, provides an opportunity to contrast the structure of IG and TCR genes from previously studied Squamata. This study revealed ten immunoglobulin genes: five genes for immunoglobulin M (IgM), two for immunoglobulin D (IgD), one for immunoglobulin D2 (IgD2), and two for immunoglobulin Y (IgY). As in other Squamata, there are genes for the λ light chain (IGLV) but not for the κ chain (IGKV). Here, the data shows that in some IgM genes, the cysteine needed to bind the λ chains does not exist, but we present evidence for possible non-covalent binding to the light chain. With respect to TCR, one gene is detected for the α constant chain (TRAC) and two genes for the β constant chain (TRBC); one of which is located in the locus of the variable regions of the heavy chain. As in the rest of the Squamata, genes for the γ/δ T cell receptor were not found. The V gene repertoire is found to be consistent with all other Squamata with few V genes for beta chain of TCR.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)