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Tytuł:
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Parental occupational pesticide exposure and nonsyndromic orofacial clefts.
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Autorzy:
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Suhl J; a Department of Epidemiology , College of Public Health, The University of Iowa , Iowa City , Iowa.
Romitti PA; a Department of Epidemiology , College of Public Health, The University of Iowa , Iowa City , Iowa.
Rocheleau C; b National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention , Cincinnati , Ohio.
Cao Y; a Department of Epidemiology , College of Public Health, The University of Iowa , Iowa City , Iowa.
Burns TL; a Department of Epidemiology , College of Public Health, The University of Iowa , Iowa City , Iowa.
Conway K; a Department of Epidemiology , College of Public Health, The University of Iowa , Iowa City , Iowa.
Bell EM; c Department of Epidemiology and Biostatistics, School of Public Health , State University of New York at Albany , Rensselaer , New York.
Stewart P; d Stewart Exposure Assessments, LLC , Arlington , Virginia.
Langlois P; e Birth Defects Epidemiology and Surveillance Branch , Texas Department of State Health Services , Austin , Texas.
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Corporate Authors:
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National Birth Defects Prevention Study
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Źródło:
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Journal of occupational and environmental hygiene [J Occup Environ Hyg] 2018 Sep; Vol. 15 (9), pp. 641-653.
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Typ publikacji:
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Journal Article; Research Support, U.S. Gov't, P.H.S.
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Język:
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English
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Imprint Name(s):
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Publication: London : Informa Healthcare
Original Publication: Philadelphia, PA : Taylor and Francis, c2004-
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MeSH Terms:
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Brain/*abnormalities
Cleft Lip/*epidemiology
Cleft Palate/*epidemiology
Maternal Exposure/*adverse effects
Occupational Exposure/*adverse effects
Paternal Exposure/*adverse effects
Pesticides/*toxicity
Adult ; Case-Control Studies ; Cleft Lip/chemically induced ; Cleft Palate/chemically induced ; Female ; Humans ; Infant, Newborn ; Male ; Pregnancy ; Stillbirth ; United States/epidemiology
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References:
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Grant Information:
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U01DD001035 United States ACL ACL HHS; U01 DD001223 United States DD NCBDD CDC HHS; P30 ES005605 United States ES NIEHS NIH HHS; U01 DD001035 United States DD NCBDD CDC HHS; T42 OH008491 United States OH NIOSH CDC HHS
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Contributed Indexing:
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Keywords: Cleft lip; cleft palate; herbicides; insecticides; pesticides; pregnancy
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Substance Nomenclature:
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0 (Pesticides)
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SCR Disease Name:
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Orofacial Cleft 1
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Entry Date(s):
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Date Created: 20180712 Date Completed: 20191023 Latest Revision: 20210109
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Update Code:
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20240105
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PubMed Central ID:
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PMC7099602
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DOI:
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10.1080/15459624.2018.1484127
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PMID:
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29993348
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Nonsyndromic orofacial clefts are common birth defects. Reported risks for orofacial clefts associated with parental occupational pesticide exposure are mixed. To examine the role of parental pesticide exposure in orofacial cleft development in offspring, this study compared population-based case-control data for parental occupational exposures to insecticides, herbicides, and fungicides, alone or in combinations, during maternal (1 month before through 3 months after conception) and paternal (3 months before through 3 months after conception) critical exposure periods between orofacial cleft cases and unaffected controls. Multivariable logistic regression was used to estimate odds ratios, adjusted for relevant covariables, and 95% confidence intervals for any (yes, no) and cumulative (none, low [