A Summary of Electrospun Nanofibers as Drug Delivery System: Drugs Loaded and Biopolymers Used as Matrices.

Szczegóły
Abstrakt

Tytuł:: A Summary of Electrospun Nanofibers as Drug Delivery System: Drugs Loaded and Biopolymers Used as Matrices.
Autorzy:: Torres-Martinez EJ; Universidad Autonoma de Baja California, Calzada Universidad 14418, Parque Industrial Internacional, Tijuana Baja California C.P. 22390, Mexico.; Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Unidad Otay, Tijuana, Baja California, México.
Cornejo Bravo JM; Universidad Autonoma de Baja California, Calzada Universidad 14418, Parque Industrial Internacional, Tijuana Baja California C.P. 22390, Mexico.; Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Unidad Otay, Tijuana, Baja California, México.
Serrano Medina A; Universidad Autonoma de Baja California, Calzada Universidad 14418, Parque Industrial Internacional, Tijuana Baja California C.P. 22390, Mexico.; Facultad de Medicina y Psicología, Universidad Autónoma de Baja California, Unidad Otay, Tijuana, Baja California, México.
Pérez González GL; Universidad Autonoma de Baja California, Calzada Universidad 14418, Parque Industrial Internacional, Tijuana Baja California C.P. 22390, Mexico.; Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Unidad Otay, Tijuana, Baja California, México.; Escuela de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Unidad Valle de las Palmas, Tijuana, Baja California, México.
Villarreal Gómez LJ; Universidad Autonoma de Baja California, Calzada Universidad 14418, Parque Industrial Internacional, Tijuana Baja California C.P. 22390, Mexico.; Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Unidad Otay, Tijuana, Baja California, México.; Escuela de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Unidad Valle de las Palmas, Tijuana, Baja California, México.
Źródło:: Current drug delivery [Curr Drug Deliv] 2018; Vol. 15 (10), pp. 1360-1374.
Typ publikacji:: Journal Article; Review
Język:: English
Imprint Name(s):: Original Publication: Saif Zone, Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, c2004-
MeSH Terms:: Drug Delivery Systems*
Anti-Bacterial Agents/*chemistry
Antineoplastic Agents/*chemistry
Biopolymers/*chemistry
Nanofibers/*chemistry
Animals ; Humans
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Contributed Indexing:: Keywords: Biopolymers; controlled release; drug release; electrospinning; fast release; nanofibers.
Substance Nomenclature:: 0 (Anti-Bacterial Agents)
0 (Antineoplastic Agents)
0 (Biopolymers)
Entry Date(s):: Date Created: 20180724 Date Completed: 20190228 Latest Revision: 20231005
Update Code:: 20240105
PubMed Central ID:: PMC6376322
DOI:: 10.2174/1567201815666180723114326
PMID:: 30033869
: Czasopismo naukowe

Recently, electrospun polymeric nanofibers have proven to be an interesting strategy for drug delivery systems application. The high surface-to-volume ratio of the fibers can improve some processes, such as cell binding and proliferation, drug loading, and mass transfer processes. One of the most important and studied areas of electrospinning is in the drug delivery field, for the controlled release of active substances ranging from antibiotics and anticancer agents to macromolecules such as proteins and DNA. The advantage of this method is that a wide variety of low solubility drugs can be loaded into the fibers to improve their bioavailability or to attain controlled release. This review presents an overview of the reported drugs loaded into polymeric nanofibers, to be used as drug delivery systems. For instance, it presents the reports on drugs with different bioactivities such as antiinflammatory, anti-microbial, anticancer, cardiovascular, anti-histamine, gastrointestinal, palliative and contraceptive drugs, etc. It also analyzes the electrospinning techniques used in each system, as well as the polymers used as matrices for the preparation of the nanofibers; unfolding the advantages of electrospun polymeric nanofibers over other drug delivery systems. This review intends to enlist and summarize the reported literature concerning this topic. In addition, it proposes future research in the field.
(Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)

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