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Tytuł pozycji:

First validation of the G-8 geriatric screening tool in older patients with glioblastoma.

Tytuł:
First validation of the G-8 geriatric screening tool in older patients with glioblastoma.
Autorzy:
Deluche E; Department of Medical Oncology, University Hospital, Limoges 87042, France. Electronic address: .
Leobon S; Department of Medical Oncology, University Hospital, Limoges 87042, France.
Lamarche F; Department of Medical Oncology, University Hospital, Limoges 87042, France.
Tubiana-Mathieu N; Department of Medical Oncology, University Hospital, Limoges 87042, France.
Źródło:
Journal of geriatric oncology [J Geriatr Oncol] 2019 Jan; Vol. 10 (1), pp. 159-163. Date of Electronic Publication: 2018 Jul 20.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Amsterdam : Elsevier
MeSH Terms:
Brain Neoplasms/*diagnosis
Geriatric Assessment/*methods
Glioblastoma/*diagnosis
Age Factors ; Aged ; Aged, 80 and over ; Brain Neoplasms/mortality ; Female ; Glioblastoma/mortality ; Humans ; Male ; Multivariate Analysis ; Prognosis ; Reproducibility of Results ; Retrospective Studies ; Survival Analysis
Contributed Indexing:
Keywords: Adjuvant therapy; G8 screening score; Glioblastoma; Older patients; Prognosis
Entry Date(s):
Date Created: 20180725 Date Completed: 20200407 Latest Revision: 20200408
Update Code:
20240105
DOI:
10.1016/j.jgo.2018.07.002
PMID:
30037767
Czasopismo naukowe
Introduction: Management of glioblastoma, with a very poor prognosis, remains a challenge in older patients because of coexisting comorbidities and the increased risk of toxic treatment effects. The use of screening tools to identify vulnerable patients is essential. This study was performed to establish whether the G8 scale can be used for screening older patients with glioblastoma.
Methods: We retrospectively reviewed the files of patients assessed by the G8 scale and diagnosed with glioblastoma at a single center from January 2010 to July 2017. Patients aged 65 years or older were classified into three groups (more efficiently than two groups) according to their G8 score to identify those with a poor prognosis: high score group, G8 score 14.5-17; intermediate score group, G8 score 10.5-14; and low score group, G8 score < 10.5.
Results: Of 89 patients, 19% were classified into the high score group, 43% into the intermediate score group, and 38% into the low score group. Median overall survival was four months in the low score group, 15 months in the intermediate score group, and 42 months in the high score group (p < .0001). On multivariate analysis, G8 score was a significant independent predictor of overall survival (hazard ratio: 55.46; 99.5% confidence interval: 13.42-229.13; p < .0001).
Conclusions: Here, we highlighted the possibility of using the G8 score, with possibly three cut-offs, in the management of older patients with glioblastoma and determined the prognostic role of this quick and easy screening tool.
(Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.)

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