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Tytuł pozycji:

Possible Roles of Mitochondrial Dynamics and the Effects of Pharmacological Interventions in Chemoresistant Ovarian Cancer.

Tytuł:
Possible Roles of Mitochondrial Dynamics and the Effects of Pharmacological Interventions in Chemoresistant Ovarian Cancer.
Autorzy:
Kingnate C; Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, Thailand; Department of Obstetrics and Gynecology, Lamphun Hospital, Lamphun, Thailand.
Charoenkwan K; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Kumfu S; Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, Thailand; Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Chattipakorn N; Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, Thailand; Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Chattipakorn SC; Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, Thailand; Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand. Electronic address: .
Źródło:
EBioMedicine [EBioMedicine] 2018 Aug; Vol. 34, pp. 256-266. Date of Electronic Publication: 2018 Jul 23.
Typ publikacji:
Journal Article; Review
Język:
English
Imprint Name(s):
Original Publication: [Amsterdam] : Elsevier B.V., [2014]-
MeSH Terms:
Drug Resistance, Neoplasm*
Antineoplastic Agents/*pharmacology
Mitochondrial Dynamics/*drug effects
Ovarian Neoplasms/*physiopathology
Animals ; Female ; Humans ; Ovarian Neoplasms/drug therapy
References:
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Contributed Indexing:
Keywords: Mitochondrial dynamics; Mitochondrial fission; Mitochondrial fusion; Ovarian cancer
Substance Nomenclature:
0 (Antineoplastic Agents)
Entry Date(s):
Date Created: 20180728 Date Completed: 20181211 Latest Revision: 20210109
Update Code:
20220902
PubMed Central ID:
PMC6116427
DOI:
10.1016/j.ebiom.2018.07.026
PMID:
30049609
Czasopismo naukowe
Ovarian cancer is the major cause of death out of all the gynecologic cancers. The prognosis of this cancer is quite poor since patients only seek treatment when it is at an advanced stage. Any early biomarkers for this cancer are still unknown. Dysregulation of mitochondrial dynamics with associated resistance to apoptosis plays a crucial role in several types of human carcinogenesis, including ovarian cancers. Previous studies showed that increased mitochondrial fission occurred in ovarian cancer cells. However, several pharmacological interventions and therapeutic strategies, which modify the mitochondrial dynamics through the promotion of mitochondrial fission and apoptosis of cancer cells, have been shown to potentially provide beneficial effects in ovarian cancer treatment. Therefore the aim of the present review is to summarize and discuss the current findings from in vitro, in vivo and clinical studies associated with the alteration of mitochondrial dynamics and ovarian cancers with and without interventions.
(Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.)

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