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Tytuł:
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Sleep Duration and Risk of Fatal Coronary Heart Disease, Sudden Cardiac Death, Cancer Death, and All-Cause Mortality.
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Autorzy:
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Khan H; Division of Cardiology, Emory University, Atlanta, Ga. Electronic address: .
Kella D; Mayo Clinic, Rochester, Minn.
Kunutsor SK; National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol and Translational Health Sciences, Bristol Medical School, Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, UK.
Savonen K; Kuopio Research Institute of Exercise Medicine.
Laukkanen JA; Institute of Public Health and Clinical Nutrition, Department of Medicine, University of Eastern Finland, Kuopio; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland and Central Finland Hospital District, Department of Medicine, Jyväskylä.
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Źródło:
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The American journal of medicine [Am J Med] 2018 Dec; Vol. 131 (12), pp. 1499-1505.e2. Date of Electronic Publication: 2018 Aug 01.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: New York, NY : Excerpta Medica
Original Publication: New York, Donnelly.
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MeSH Terms:
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Coronary Disease/*etiology
Coronary Disease/*mortality
Death, Sudden, Cardiac/*etiology
Neoplasms/*etiology
Neoplasms/*mortality
Sleep Deprivation/*complications
Adult ; Cause of Death ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Risk Factors
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Contributed Indexing:
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Keywords: Cancer death; Coronary heart disease; Sleep duration; Sudden cardiac death
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Entry Date(s):
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Date Created: 20180805 Date Completed: 20190911 Latest Revision: 20190911
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Update Code:
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20240104
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DOI:
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10.1016/j.amjmed.2018.07.010
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PMID:
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30076817
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Background: Sleep duration has been shown to be associated with all-cause mortality; however, its relationship with cause-specific fatal events remains uncertain. We examined the relationship between sleep duration and risk of fatal coronary heart disease, sudden cardiac death, cancer-related death, and all-cause mortality.
Methods: Sleep duration was self-reported at baseline examinations performed between March 20, 1984, and December 5, 1989, in 2361 men aged 42-61 years from the Kuopio Ischemic Heart Disease study. Of these, 1734 (73.4%) men were free from coronary heart disease and cancer at baseline.
Results: A total of 802 all-cause deaths, 202 fatal coronary heart disease events, 141 sudden cardiac events, and 229 cancer-related deaths were reported during a median follow-up of 25.9 (interquartile range, 20.6-28.2) years. Multivariable adjusted hazard ratios comparing the top quartile (>10 hours) of sleep duration vs the bottom quartile (<8 hours) was 1.19 (95% confidence interval [CI], 1.01-1.43) for all-cause mortality, 1.27 (95% CI, 0.88-1.84) for fatal coronary heart disease, 1.20 (95% CI, 0.78-1.86) for sudden cardiac death, and 1.29 (95% CI, 0.92-1.80) for cancer death. No differences in association of sleep duration with outcomes were found in clinically relevant subgroups, including age, history of coronary heart disease, body mass index, physical activity, and C-reactive protein levels.
Conclusions: Longer duration of sleep was associated with significantly increased all-cause mortality. The mechanistic link between these findings remains to be explored further.
(Copyright © 2018. Published by Elsevier Inc.)
Comment in: Am J Med. 2019 Jan;132(1):e26. (PMID: 30573218)
Comment in: Am J Med. 2019 Jan;132(1):e27. (PMID: 30573219)
