Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Equivalent Hypertrophy and Strength Gains in β-Hydroxy-β-Methylbutyrate- or Leucine-supplemented Men.

Tytuł :
Equivalent Hypertrophy and Strength Gains in β-Hydroxy-β-Methylbutyrate- or Leucine-supplemented Men.
Autorzy :
Jakubowski JS; Department of Kinesiology, McMaster University, Ontario, CANADA.
Wong EPT; Department of Kinesiology, McMaster University, Ontario, CANADA.
Nunes EA; Department of Physiological Sciences, Federal University of Santa Catarina, Florianopólis, BRAZIL.
Noguchi KS; Department of Kinesiology, McMaster University, Ontario, CANADA.
Vandeweerd JK; Department of Kinesiology, McMaster University, Ontario, CANADA.
Murphy KT; Department of Kinesiology, McMaster University, Ontario, CANADA.
Morton RW; Department of Kinesiology, McMaster University, Ontario, CANADA.
McGlory C; Department of Kinesiology, McMaster University, Ontario, CANADA.
Phillips SM; Department of Kinesiology, McMaster University, Ontario, CANADA.
Pokaż więcej
Źródło :
Medicine and science in sports and exercise [Med Sci Sports Exerc] 2019 Jan; Vol. 51 (1), pp. 65-74.
Typ publikacji :
Journal Article; Pragmatic Clinical Trial; Randomized Controlled Trial
Język :
English
Imprint Name(s) :
Publication: Hagerstown, Md : Lippincott Williams & Wilkins
Original Publication: Madison, Wis., American College of Sports Medicine.
MeSH Terms :
Dietary Supplements*
Resistance Training*
Leucine/*administration & dosage
Muscle Strength/*physiology
Muscle, Skeletal/*anatomy & histology
Muscle, Skeletal/*physiology
Performance-Enhancing Substances/*administration & dosage
Valerates/*administration & dosage
Adult ; Biopsy ; Body Composition ; Creatine Kinase/blood ; Double-Blind Method ; Human Growth Hormone/blood ; Humans ; Hydrocortisone/blood ; Insulin-Like Growth Factor I/metabolism ; Male ; Muscle, Skeletal/diagnostic imaging ; Testosterone/blood ; Ultrasonography ; Young Adult
References :
J Int Soc Sports Nutr. 2013 Feb 02;10(1):6. (PMID: 23374455)
Can J Appl Physiol. 2002 Aug;27(4):415-22. (PMID: 12442354)
Int J Sport Nutr Exerc Metab. 2001 Sep;11(3):384-96. (PMID: 11599506)
Br J Nutr. 2011 Feb;105(3):367-72. (PMID: 21134325)
J Strength Cond Res. 2014 Nov;28(11):3293-7. (PMID: 24845210)
J Strength Cond Res. 2017 Mar 13;31(5):e71-e72. (PMID: 28301440)
J Am Coll Nutr. 2014;33(4):247-55. (PMID: 25140763)
Eur J Appl Physiol. 2014 Jun;114(6):1217-27. (PMID: 24599749)
Br J Nutr. 2013 Aug 28;110(3):538-44. (PMID: 23286834)
Nutrients. 2017 Jul 14;9(7):. (PMID: 28708126)
Int J Sport Nutr Exerc Metab. 2001 Dec;11(4):442-50. (PMID: 11915779)
J Physiol. 2009 Nov 1;587(Pt 21):5239-47. (PMID: 19736298)
J Appl Physiol (1985). 2016 Jul 1;121(1):129-38. (PMID: 27174923)
Curr Sports Med Rep. 2010 Jul-Aug;9(4):208-13. (PMID: 20622538)
J Strength Cond Res. 2018 Aug;32(8):2154-2165. (PMID: 28704309)
PLoS One. 2012;7(4):e35273. (PMID: 22530000)
J Int Soc Sports Nutr. 2015 Jul 30;12:31. (PMID: 26225130)
J Appl Physiol (1985). 2005 Jun;98(6):1985-90. (PMID: 15705728)
J Appl Physiol (1985). 1996 Nov;81(5):2095-104. (PMID: 8941534)
Clin Physiol Funct Imaging. 2018 May;38(3):396-401. (PMID: 28444941)
Clin Nutr. 2018 Dec;37(6 Pt A):2068-2075. (PMID: 29097038)
Scand J Med Sci Sports. 2018 Mar;28(3):846-853. (PMID: 28805932)
Nutr Metab (Lond). 2016 Sep 29;13:64. (PMID: 27708684)
Med Sci Sports Exerc. 2009 May;41(5):1111-21. (PMID: 19346975)
Curr Opin Clin Nutr Metab Care. 2008 May;11(3):222-6. (PMID: 18403916)
Int J Sport Nutr Exerc Metab. 2005 Apr;15(2):195-210. (PMID: 16089277)
J Nutr Metab. 2012;2012:960363. (PMID: 22288008)
Int J Sports Med. 1999 Nov;20(8):503-9. (PMID: 10606212)
Int J Sport Nutr Exerc Metab. 2003 Jun;13(2):184-97. (PMID: 12945829)
J Am Coll Nutr. 2018 Sep-Oct;37(7):640-649. (PMID: 29676656)
J Strength Cond Res. 2016 Jul;30(7):1843-54. (PMID: 24714541)
Int J Sport Nutr Exerc Metab. 2004 Feb;14(1):104-20. (PMID: 15129934)
J Strength Cond Res. 2016 Sep;30(9):2617-26. (PMID: 26849784)
J Physiol. 2013 Jun 1;591(11):2911-23. (PMID: 23551944)
J Appl Physiol (1985). 2000 Oct;89(4):1340-4. (PMID: 11007567)
Eur J Appl Physiol. 2004 Jan;91(1):116-8. (PMID: 14639480)
Appl Physiol Nutr Metab. 2013 Feb;38(2):220-6. (PMID: 23438236)
J Strength Cond Res. 2009 May;23(3):827-35. (PMID: 19387396)
Nutr Metab (Lond). 2017 Jul 4;14:42. (PMID: 28680453)
Br J Sports Med. 2018 Mar;52(6):376-384. (PMID: 28698222)
Substance Nomenclature :
0 (IGF1 protein, human)
0 (Performance-Enhancing Substances)
0 (Valerates)
12629-01-5 (Human Growth Hormone)
3F752311CD (beta-hydroxyisovaleric acid)
3XMK78S47O (Testosterone)
67763-96-6 (Insulin-Like Growth Factor I)
EC 2.7.3.2 (Creatine Kinase)
GMW67QNF9C (Leucine)
WI4X0X7BPJ (Hydrocortisone)
Entry Date(s) :
Date Created: 20180817 Date Completed: 20190814 Latest Revision: 20210203
Update Code :
20210210
PubMed Central ID :
PMC6303132
DOI :
10.1249/MSS.0000000000001752
PMID :
30113522
Czasopismo naukowe
Ingestion of proteins with high leucine content during resistance training (RT) can augment hypertrophy. Some data suggest that a leucine metabolite, β-hydroxy, β-methylbutyrate (HMB), is substantially more anabolically efficacious than leucine.
Purpose: We aimed to test whether supplementation with HMB versus leucine, added to whey protein, would result in differential muscle hypertrophy and strength gains in young men performing RT.
Methods: Twenty-six resistance-trained men (23 ± 2 yr) performed 12 wk of RT with three phases. Phase 1: 8 wk of periodized RT (three training sessions per week). Phase 2: 2 wk overreaching period (five sessions per week). Phase 3: 2 wk taper (three sessions per week). Participants were randomly assigned to twice daily ingestion of: whey protein (25 g) plus HMB (1.5 g) (whey+HMB; n = 13) or whey protein (25 g) plus leucine (1.5 g) (whey+leu; n = 13). Skeletal muscle biopsies were performed before and after RT. Measures of fat- and bone-free mass, vastus lateralis (VL) muscle thickness and muscle cross-sectional area (CSA) (both by ultrasound), muscle fiber CSA, and 1-repetition maximum (1-RM) strength tests were determined.
Results: We observed increases in fat- and bone-free mass, VL muscle thickness, muscle CSA and fiber type CSA and 1-RM strength with no differences between groups at any phase. We observed no differences between groups or time-group interactions in hormone concentrations at any phase of the RT program.
Conclusions: β-Hydroxy-β-methylbutyrate added to whey did not result in greater increases in any measure of muscle mass, strength, or hormonal concentration compared to leucine added to whey. Our results show that HMB is no more effective in stimulating RT-induced hypertrophy and strength gains than leucine.
Erratum in: Med Sci Sports Exerc. 2021 Jan;53(1):247. (PMID: 33323831)

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies