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Tytuł:
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Low incidence of and mortality from a second malignancy after resection of thymic carcinoma†.
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Autorzy:
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Hamaji M; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kawaguchi A; Center for Comprehensive Community Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Omasa M; Department of Thoracic Surgery, Nishi Kobe Medical Center, Kobe, Japan.
Nakagawa T; Department of Thoracic Surgery, Tenri Hospital, Nara, Japan.
Sumitomo R; Department of Thoracic Surgery, Kitano Hospital, Osaka, Japan.
Huang CL; Department of Thoracic Surgery, Kitano Hospital, Osaka, Japan.
Fujinaga T; Department of Thoracic Surgery, National Hospital Organization Nagara Medical Center, Gifu, Japan.
Ikeda M; Department of Thoracic Surgery, National Hospital Organization Nagara Medical Center, Gifu, Japan.
Shoji T; Department of Thoracic Surgery, Otsu Red Cross Hospital, Shiga, Japan.
Katakura H; Department of Thoracic Surgery, Otsu Red Cross Hospital, Shiga, Japan.
Motoyama H; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Menju T; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Aoyama A; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sato T; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Chen-Yoshikawa TF; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sonobe M; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Date H; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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Źródło:
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Interactive cardiovascular and thoracic surgery [Interact Cardiovasc Thorac Surg] 2019 Mar 01; Vol. 28 (3), pp. 375-379.
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Typ publikacji:
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Journal Article; Multicenter Study
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Język:
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English
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Imprint Name(s):
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Publication: 2012-2022 : Oxford, England : Oxford University Press
Original Publication: Amsterdam, The Netherlands ; New York : Elsevier Science, c2002-
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MeSH Terms:
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Neoplasms, Second Primary/*epidemiology
Thymectomy/*methods
Thymoma/*surgery
Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Incidence ; Japan/epidemiology ; Male ; Middle Aged ; Retrospective Studies ; Thymoma/diagnosis ; Young Adult
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Contributed Indexing:
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Keywords: Second malignancy; Surgery; Thymic carcinoma; Thymic neuroendocrine carcinoma; Thymoma
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Entry Date(s):
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Date Created: 20180824 Date Completed: 20190812 Latest Revision: 20190812
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Update Code:
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20240105
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DOI:
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10.1093/icvts/ivy260
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PMID:
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30137401
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Objectives: Previous studies have suggested that a second malignancy often develops after resection of thymoma; however, it remains unknown whether this is applicable to thymic carcinoma.
Methods: A retrospective chart review was performed based on our multi-institutional database of resected thymic epithelial tumours between 1991 and 2016. A second malignancy was defined as newly diagnosed after thymic tumour resection. The cumulative incidence of and related death from a second malignancy after thymic and neuroendocrine carcinoma resections were estimated using a competing risk model and were compared to those of patients undergoing a thymoma resection.
Results: Two hundred and thirty-eight patients were identified (thymic carcinoma 59; thymoma 179). A second malignancy developed in 1 patient (1.7%) with thymic carcinoma and in 17 patients (9.5%) with thymoma. Deaths from second malignancies were noted in 7 patients with thymoma. There was a tendency towards a lower cumulative incidence of and a lower cumulative death from a second malignancy after thymic carcinoma resection (P = 0.139 and P = 0.20, respectively) than after thymoma resection. The cumulative incidence of a second malignancy in patients with thymic carcinoma was 2.8% at 5 years and at 10 years (8.0% at 5 years and 11.8% at 10 years in patients with thymoma).
Conclusions: After resection of thymic and thymic neuroendocrine carcinoma, the probability of developing a second malignancy, as well as mortality from a second malignancy, is very low. A prospective study with a larger sample size is required to validate our results.
(© The Author(s) 2018. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)