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Tytuł pozycji:

Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease.

Tytuł:
Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease.
Autorzy:
Olabode OP; HOPE Cardiometabolic Research Team, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.; Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
Akinlade OM; Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.; Department of Medicine, Ladoke Akintola University of Technology Teaching Hospital, Ogbomoso, Nigeria.
Babatunde AS; Department of Haematology and Blood Transfusion, College of Health Sciences, University of Ilorin, Nigeria.
Abdulazeez MI; Department of Chemical Pathology and Immunology, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
Biliaminu SA; Department of Chemical Pathology and Immunology, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
Oyabambi AO; HOPE Cardiometabolic Research Team, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.; Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
Olatunji VA; HOPE Cardiometabolic Research Team, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.; Department of Ophthalmology, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
Soladoye AO; Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
Olatunji LA; HOPE Cardiometabolic Research Team, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.; Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
Źródło:
Archives of physiology and biochemistry [Arch Physiol Biochem] 2020 May; Vol. 126 (2), pp. 166-171. Date of Electronic Publication: 2018 Aug 25.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: London : Informa Healthcare
Original Publication: Lisse, Netherlands : Swets & Zeitlinger, c1995-
MeSH Terms:
Blood Pressure*
Cholesterol, HDL/*blood
Hemoglobin SC Disease/*diagnosis
Plasminogen Activator Inhibitor 1/*blood
Sickle Cell Trait/*diagnosis
Triglycerides/*blood
Adolescent ; Adult ; Biomarkers/blood ; Female ; Hemoglobin A/metabolism ; Hemoglobin SC Disease/blood ; Hemoglobin, Sickle/metabolism ; Humans ; Linear Models ; Male ; ROC Curve ; Sickle Cell Trait/blood
Contributed Indexing:
Keywords: Plasminogen activator inhibitor-1; pulse pressure; sickle cell disease; sickle cell trait; triglyceride/high-density lipoprotein ratio
Substance Nomenclature:
0 (Biomarkers)
0 (Cholesterol, HDL)
0 (Hemoglobin, Sickle)
0 (Plasminogen Activator Inhibitor 1)
0 (Triglycerides)
37248-06-9 (hemoglobin AA)
52012-19-8 (hemoglobin AS)
9034-51-9 (Hemoglobin A)
Entry Date(s):
Date Created: 20180828 Date Completed: 20200323 Latest Revision: 20200323
Update Code:
20240105
DOI:
10.1080/13813455.2018.1499118
PMID:
30145922
Czasopismo naukowe
We hypothesised that TG/HDL-C ratio and PAI-1 would be associated with high pulse pressure (PP) in young adults with sickle cell trait (SCT) and sickle cell disease (SCD). We compared the clinical, biochemical, and cardiometabolic parameters among individuals with normal genotype (HbAA; n  = 60), SCT (HbAS; n  = 60), and SCD (HbSS; n  = 60), all in steady state. Using multivariate linear regression analysis, high PP was positively related to TG/HDL-C ratio in SCT (β = 0.307; p  = .014) and PAI-1 (β = 0.499; p  = .001) in SCD. The curve of receiver operating characteristic also showed that TG/HDL-C ratio and PAI-1 are efficient predictors of high PP in SCT carriers and SCD patients, respectively. This study suggests that increased levels of TG/HDL-C ratio and PAI-1 may be salient risk factors that would promote the development of arterial stiffness and other CVD in SCT carriers and SCD patients.
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