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Tytuł pozycji:

Regio and stereoselective synthesis of anticancer spirooxindolopyrrolidine embedded piperidone heterocyclic hybrids derived from one-pot cascade protocol.

Tytuł :
Regio and stereoselective synthesis of anticancer spirooxindolopyrrolidine embedded piperidone heterocyclic hybrids derived from one-pot cascade protocol.
Autorzy :
Arumugam N; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia. .
Almansour AI; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Kumar RS; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Al-Thamili DM; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Periyasami G; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Periasamy VS; Nanobiotecnology and Molecular Biology Research Laboratory, Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia.
Athinarayanan J; Nanobiotecnology and Molecular Biology Research Laboratory, Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia.
Alshatwi AA; Nanobiotecnology and Molecular Biology Research Laboratory, Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia.
Mahalingam SM; Department of Atomic and Molecular Physics, MIT Campus, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Menéndez JC; Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040, Madrid, Spain.
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Źródło :
Chemistry Central journal [Chem Cent J] 2018 Sep 01; Vol. 12 (1), pp. 95. Date of Electronic Publication: 2018 Sep 01.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: [London, United Kingdom] : BioMed Central
Original Publication: London : Chemistry Central Ltd., in association with BioMed Central, c2007-
References :
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Grant Information :
Research group No. RG-1438-052. The authors thank the Deanship of Scientific Research at King Saud University for funding this work through research group No. RG-1438-052.
Contributed Indexing :
Keywords: Antiproliferative activity; Apoptosis induction; Chemo divergent multicomponent reactions; Domino reactions; Piperidone; Spiropyrrolidine
Entry Date(s) :
Date Created: 20180903 Latest Revision: 20201001
Update Code :
20210623
PubMed Central ID :
PMC6119554
DOI :
10.1186/s13065-018-0462-x
PMID :
30173362
Czasopismo naukowe
Background: Spiropyrrolidine tethered piperidone heterocyclic hybrids were synthesized with complete regio- and stereoselectively in excellent yield via a tandem three-component 1,3-dipolar cycloaddition and subsequent enamine reaction in [bmim]Br. The synthesized compounds were evaluated for their anticancer activity against FaDu hypopharyngeal tumor cells.
Findings: Interestingly, most compounds displayed cytotoxicities similar to the standard anticancer agent bleomycin, with two of them (5a and 5g) being slightly more active than the reference drug.
Conclusion: Synthesized compounds have also been evaluated for their apoptosis-inducing properties in a cancer cell model, finding that treatment with compounds 5a-e led to apoptotic cell death.
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