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Tytuł pozycji:

15d-PGJ 2 -loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice.

Tytuł:
15d-PGJ 2 -loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice.
Autorzy:
Ruiz-Miyazawa KW; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paraná, Brazil.
Staurengo-Ferrari L; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paraná, Brazil.
Pinho-Ribeiro FA; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paraná, Brazil.
Fattori V; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paraná, Brazil.
Zaninelli TH; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paraná, Brazil.
Badaro-Garcia S; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paraná, Brazil.
Borghi SM; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paraná, Brazil.
Andrade KC; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paraná, Brazil.
Clemente-Napimoga JT; Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Researcher Center, Campinas, Brazil.
Alves-Filho JC; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes s/n, 14050-490, Ribeirão Preto, São Paulo, Brazil.
Cunha TM; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes s/n, 14050-490, Ribeirão Preto, São Paulo, Brazil.
Fraceto LF; Department of Environmental Engineering, São Paulo State University, Sorocaba, Brazil.
Cunha FQ; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes s/n, 14050-490, Ribeirão Preto, São Paulo, Brazil.
Napimoga MH; Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Researcher Center, Campinas, Brazil.
Casagrande R; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina-UEL, Avenida Robert Koch, 60, Hospital Universitário, 86038-350, Londrina, Paraná, Brazil.
Verri WA Jr; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paraná, Brazil. .
Źródło:
Scientific reports [Sci Rep] 2018 Sep 18; Vol. 8 (1), pp. 13979. Date of Electronic Publication: 2018 Sep 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:
Arthritis, Experimental/*prevention & control
Arthritis, Gouty/*prevention & control
Inflammation/*drug therapy
Nanocapsules/*administration & dosage
PPAR gamma/*metabolism
Pain/*drug therapy
Prostaglandin D2/*analogs & derivatives
Animals ; Antioxidants/toxicity ; Arthritis, Experimental/metabolism ; Arthritis, Experimental/pathology ; Arthritis, Gouty/metabolism ; Arthritis, Gouty/pathology ; Inflammation/chemically induced ; Inflammation/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Oxidative Stress ; Pain/chemically induced ; Pain/metabolism ; Prostaglandin D2/pharmacology ; Uric Acid/toxicity
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Substance Nomenclature:
0 (15-deoxyprostaglandin J2)
0 (Antioxidants)
0 (Nanocapsules)
0 (PPAR gamma)
268B43MJ25 (Uric Acid)
RXY07S6CZ2 (Prostaglandin D2)
Entry Date(s):
Date Created: 20180920 Date Completed: 20191114 Latest Revision: 20191114
Update Code:
20240105
PubMed Central ID:
PMC6143605
DOI:
10.1038/s41598-018-32334-0
PMID:
30228306
Czasopismo naukowe
Gout arthritis (GA) is a painful inflammatory disease in response to monosodium urate (MSU) crystals in the joints. 15deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ 2 ) is a natural activator of PPAR-γ with analgesic, anti-inflammatory, and pro-resolution properties. Thus, we aimed to evaluate the effect and mechanisms of action of 15d-PGJ 2 nanocapsules (NC) in the model of GA in mice, since a reduction of 33-fold in the dose of 15d-PGJ 2 has been reported. Mice were treated with 15d-PGJ 2 -loaded NC, inert NC, free 15d-PGJ 2 (without NC), or 15d-PGJ 2 -loaded NC+ GW9662, a PPAR-γ inhibitor. We show that 15d-PGJ 2 -loaded NC provided analgesic effect in a dose that the free 15d-PGJ 2 failed to inhibiting pain and inflammation. Hence, 15d-PGJ 2 -loaded NC reduced MSU-induced IL-1β, TNF-α, IL-6, IL-17, and IL-33 release and oxidative stress. Also, 15d-PGJ 2 -loaded NC decreased the maturation of IL-1β in LPS-primed BMDM triggered by MSU. Further, 15d-PGJ 2 -loaded NC decreased the expression of the components of the inflammasome Nlrp3, Asc, and Pro-caspase-1, as consequence of inhibiting NF-κB activation. All effects were PPAR-γ-sensitive. Therefore, we demonstrated that 15d-PGJ 2 -loaded NC present analgesic and anti-inflammatory properties in a PPAR-γ-dependent manner inhibiting IL-1β release and NF-κB activation in GA. Concluding, 15d-PGJ 2 -loaded NC ameliorates MSU-induced GA in a PPAR-γ-sensitive manner.
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