Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18-22 months.

Szczegóły
Abstrakt

Tytuł:: Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18-22 months.
Autorzy:: Chalak LF; University of Texas Southwestern Medical Center, Dallas, TX, USA. .
Nguyen KA; McGill University Health Center, Montreal, QC, Canada.
Prempunpong C; Mahidol University, Bangkok, Thailand.
Heyne R; University of Texas Southwestern Medical Center, Dallas, TX, USA.
Thayyil S; Imperial College, London, UK.
Shankaran S; Wayne State University, Detroit, MI, USA.
Laptook AR; Brown University, Providence, RI, USA.
Rollins N; University of Texas Southwestern Medical Center, Dallas, TX, USA.
Pappas A; Wayne State University, Detroit, MI, USA.
Koclas L; McGill University Health Center, Montreal, QC, Canada.
Shah B; Brown University, Providence, RI, USA.
Montaldo P; Imperial College, London, UK.
Techasaensiri B; Mahidol University, Bangkok, Thailand.
Sánchez PJ; Center for Perinatal Research, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA.
Sant'Anna G; McGill University Health Center, Montreal, QC, Canada.
Źródło:: Pediatric research [Pediatr Res] 2018 Dec; Vol. 84 (6), pp. 861-868. Date of Electronic Publication: 2018 Sep 13.
Typ publikacji:: Journal Article; Multicenter Study; Observational Study; Research Support, N.I.H., Extramural
Język:: English
Imprint Name(s):: Publication: 2012- : New York : Nature Publishing Group
Original Publication: Basel ; New York : Karger.
MeSH Terms:: Brain Diseases/*diagnosis
Brain Diseases/*therapy
Hypoxia-Ischemia, Brain/*diagnosis
Hypoxia-Ischemia, Brain/*therapy
Autistic Disorder/diagnosis ; Birth Weight ; Brain/diagnostic imaging ; Cerebral Palsy/diagnosis ; Cognition ; Developmental Disabilities/diagnosis ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; International Cooperation ; Magnetic Resonance Imaging ; Neurologic Examination ; Prospective Studies ; Severity of Illness Index ; Treatment Outcome
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Grant Information:: K23 HD069521 United States HD NICHD NIH HHS; MR/R001375/1 United Kingdom MRC_ Medical Research Council; NIHR/CS/010/022 United Kingdom DH_ Department of Health; R01 NS102617 United States NS NINDS NIH HHS
Entry Date(s):: Date Created: 20180926 Date Completed: 20191029 Latest Revision: 20210109
Update Code:: 20240105
PubMed Central ID:: PMC6445543
DOI:: 10.1038/s41390-018-0174-x
PMID:: 30250303
: Czasopismo naukowe

Background: Studies of early childhood outcomes of mild hypoxic-ischemic encephalopathy (HIE) identified in the first 6 h of life are lacking.
Objective: To evaluate neurodevelopmental outcomes at 18-22 months of PRIME study.
Study Design: Multicenter, prospective study of mild HIE defined as ≥1 abnormality using the modified Sarnat within 6 h of birth and not meeting cooling criteria. Primary outcome was disability with mild: Bayley III cognitive 70-84 or ≥85 and either Gross Motor Function Classification System (GMFCS) 1 or 2, seizures, or hearing deficit; moderate: cognitive 70-84 and either GMFCS 2, seizures, or hearing deficit; severe: cognitive <70, GMFCS 3-5.
Results: Of the 63 infants enrolled, 51 (81%) were evaluated at 19 ± 2 months and 43 (68%) completed Bayley III. Of the 43 infants, 7 (16%) were diagnosed with disability, including 1 cerebral palsy and 2 autism. Bayley scores < 85 in either cognition, motor, or language were detected in 17 (40%): 14 (32%) language, 7 (16%) cognitive, and 6 (14%) motor domain. Infants with disability had more abnormalities on discharge examination and brain MRI, with longer hospital stay (p < 0.001).
Conclusions: In this contemporary untreated cohort of mild HIE, disability occurred in 16% of infants at 18-22 months.

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