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Tytuł:
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Late-onset cardiomyopathy among survivors of childhood lymphoma treated with anthracyclines: a systematic review.
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Autorzy:
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Benetou DR; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: .
Stergianos E; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Geropeppa M; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Ntinopoulou E; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Tzanni M; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Pourtsidis A; Department of Pediatric Hematology-Oncology, 'Pan. &Agl. Kyriakou' Children's Hospital, Athens, Greece.
Petropoulos AC; Department of Pediatric Cardiology, XMSK & Merkezi Hospital, National Medical University and the 'Aziz Aliyev' National Postgraduate and CME Medical Training Center, Baku, Azerbaijan.
Georgakis MK; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Tousoulis D; 1(st) Department of Cardiology, Athens University Medical School, 'Hippokration' Hospital, Athens, Greece.
Petridou ET; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Unit of Clinical Epidemiology, Medical School, Karolinska Institute, Stockholm, Sweden.
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Źródło:
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Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese [Hellenic J Cardiol] 2019 May - Jun; Vol. 60 (3), pp. 152-164. Date of Electronic Publication: 2018 Sep 29.
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Typ publikacji:
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Journal Article; Systematic Review
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Język:
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English
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Imprint Name(s):
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Publication: [Amsterdam] : Elsevier B.V.
Original Publication: Athens, Greece : Hellenic Cardiological Society
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MeSH Terms:
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Anthracyclines/*adverse effects
Cancer Survivors/*statistics & numerical data
Cardiomyopathies/*chemically induced
Lymphoma/*drug therapy
Age of Onset ; Cardiomyopathies/epidemiology ; Cardiotoxicity ; Child ; Global Health ; Humans ; Incidence ; Risk Factors ; Survival Rate/trends ; Time Factors
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Contributed Indexing:
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Keywords: Anthracyclines; Cardiomyopathy; Cardiotoxicity; Childhood Lymphoma; Hodgkin Disease; Non-Hodgkin
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Substance Nomenclature:
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0 (Anthracyclines)
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Entry Date(s):
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Date Created: 20181002 Date Completed: 20200309 Latest Revision: 20200309
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Update Code:
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20240105
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DOI:
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10.1016/j.hjc.2018.09.004
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PMID:
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30273645
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Medical advances in pediatric oncology have led to increases in survival but the long-term adverse effects of treatment in childhood cancer survivors have not yet been examined in depth. In this systematic review, we aimed to study the prevalence and risk factors of late-onset cardiomyopathy (LOCM) among survivors of childhood lymphoma treated with anthracyclines. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines we searched Pubmed/Medline, abstracted data and rated studies on quality regarding late-onset (>1 year following treatment) cardiotoxicity of anthracyclines in survivors of childhood lymphoma. Across 22 identified studies, the prevalence of anthracycline-induced LOCM among survivors of childhood lymphoma ranges from 0 to 40%. Anthracycline dose, administration and dose of mediastinal radiation, patient's age and era of diagnosis and evaluation, follow-up duration as well as disease relapse have been reported as risk factors for LOCM, whereas administration of dexrazoxane seems to act protectively. There was significant between-study heterogeneity with regards to lymphoma subtypes, follow-up duration, definition of outcomes, and anthracycline-based treatment protocols. The rates of anthracycline-induced LOCM among survivors of childhood lymphoma are high and dependent on study design. Future studies should explore whether modifying risk factors and suggested supportive care could decrease its prevalence among childhood lymphoma survivors. Until then, lifelong follow-up of these patients aiming to determinate the earliest signs of cardiac dysfunction is the most important measure towards primordial prevention of LOCM.
(Copyright © 2018 Hellenic Society of Cardiology. Published by Elsevier B.V. All rights reserved.)
