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Tytuł:
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Alterations in Resting-State Networks Following In Utero Selective Serotonin Reuptake Inhibitor Exposure in the Neonatal Brain.
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Autorzy:
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Rotem-Kohavi N; Graduate Program in Neuroscience, University of British Columbia, Vancouver, Canada.
Williams LJ; MRI Research Facility, BC Children's Hospital, Vancouver, Canada.
Virji-Babul N; Department of Physical Therapy, University of British Columbia, Vancouver, Canada.
Bjornson BH; Division of Neurology, University of British Columbia, Vancouver, Canada; MRI Research Facility, BC Children's Hospital, Vancouver, Canada.
Brain U; Research Institute, BC Children's Hospital, Vancouver, Canada.
Werker JF; Department of Psychology, Faculty of Arts, University of British Columbia, Vancouver, Canada.
Grunau RE; Division of Neonatology, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada; Research Institute, BC Children's Hospital, Vancouver, Canada.
Miller SP; Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
Oberlander TF; Division of Developmental Pediatrics, University of British Columbia, Vancouver, Canada; Research Institute, BC Children's Hospital, Vancouver, Canada. Electronic address: .
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Źródło:
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Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2019 Jan; Vol. 4 (1), pp. 39-49. Date of Electronic Publication: 2018 Aug 25.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: New York, NY : Elsevier, Inc., [2016]-
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MeSH Terms:
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Brain/*drug effects
Brain/*physiopathology
Mood Disorders/*drug therapy
Prenatal Exposure Delayed Effects/*physiopathology
Selective Serotonin Reuptake Inhibitors/*adverse effects
Adult ; Brain Mapping ; Female ; Humans ; Infant, Newborn ; Magnetic Resonance Imaging ; Maternal-Fetal Exchange ; Neural Pathways/drug effects ; Neural Pathways/physiopathology ; Pregnancy ; Psychiatric Status Rating Scales ; Selective Serotonin Reuptake Inhibitors/administration & dosage
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Grant Information:
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MOP-5783 Canada CIHR
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Contributed Indexing:
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Keywords: Maternal depression; Neonatal neurodevelopment; Resting-state functional MRI; Resting-state networks; SSRIs; Serotonin
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Substance Nomenclature:
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0 (Serotonin Uptake Inhibitors)
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Entry Date(s):
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Date Created: 20181008 Date Completed: 20200106 Latest Revision: 20221207
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Update Code:
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20240104
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DOI:
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10.1016/j.bpsc.2018.08.004
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PMID:
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30292808
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Background: Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat depression during pregnancy. SSRIs cross the placenta, inhibit serotonin reuptake, and thereby are thought to alter central fetal serotonin signaling. Both prenatal maternal mood disturbances and in utero SSRI exposure have been associated with altered fetal and infant behavior. Resting-state functional magnetic resonance imaging has identified resting-state networks (RSNs) in newborns, reflecting functional capacity of auditory and visual networks and providing opportunities to examine early experiences effects on neurodevelopment. We sought to examine the effect of in utero SSRI exposure on neonatal RSN functional organization. We hypothesized that prenatal SSRI exposure would be associated with alterations in neonatal RSNs compared with healthy control infants and infants exposed to mothers with depression.
Methods: Clinician-rated Hamilton Depression Rating Scale and self-reported Pregnancy Experiences Scale were completed during the third trimester. Control (n = 17), maternal depression-exposed (Hamilton Depression Rating Scale ≥8 without SSRI exposure, n = 16), and SSRI-exposed (n = 20) 6-day-old neonates underwent resting-state functional magnetic resonance imaging. Independent component analysis was used as a data-driven approach to extract 22 RSNs.
Results: SSRI-exposed neonates had higher connectivity in a putative auditory RSN compared with depressed-only (p = .01) and control (p = .02) infants (corrected for multiple comparisons), controlling for sex, age at the magnetic resonance imaging, and Pregnancy Experiences Scale score.
Conclusions: Hyperconnectivity in auditory RSN in neonates with in utero SSRI exposure relative to neonates of depressed but not pharmacologically treated mothers and control infants may offer an insight into the functional organization origins of shifts in language perception and altered language development, previously reported in infants and children with prenatal SSRI exposure.
(Copyright © 2018 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
