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Tytuł:
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Hospitalized patients with stress hyperglycemia: incidence of diabetes and mortality on follow-up.
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Autorzy:
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Russo MP; Servicio de Clínica Médica, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. Electronic address: .
Grande Ratti MF; Área de Investigación en Medicina Interna, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Servicio Medicina Familiar y Comunitaria, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Área Epidemiológica de Dirección de Promoción de la Salud y Control de Enfermedades No Transmisibles, Ministerio de Salud de Nación, Argentina.
Giunta DH; Servicio de Clínica Médica, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Área de Investigación en Medicina Interna, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Departamento de Investigación, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Elizondo CM; Servicio de Clínica Médica, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Área de Investigación en Medicina Interna, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
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Transliterated Title:
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Pacientes hospitalizados con hiperglucemia de estrés: incidencia de diabetes y mortalidad al seguimiento.
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Źródło:
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Endocrinologia, diabetes y nutricion [Endocrinol Diabetes Nutr (Engl Ed)] 2018 Dec; Vol. 65 (10), pp. 571-576. Date of Electronic Publication: 2018 Oct 04.
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Typ publikacji:
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Journal Article
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Język:
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English; Spanish; Castilian
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Imprint Name(s):
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Original Publication: [Barcelona] : [Elsevier España], 2017-
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MeSH Terms:
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Hospital Mortality*
Inpatients*
Stress, Physiological*
Diabetes Mellitus/*epidemiology
Hyperglycemia/*epidemiology
Aged ; Aged, 80 and over ; Argentina/epidemiology ; Diagnosis-Related Groups ; Female ; Follow-Up Studies ; Glycated Hemoglobin/analysis ; Hospitalization ; Hospitals, University/statistics & numerical data ; Humans ; Hyperglycemia/etiology ; Incidence ; Kaplan-Meier Estimate ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Tertiary Care Centers/statistics & numerical data
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Contributed Indexing:
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Keywords: Diabetes; Hiperglucemia de estrés; Mortalidad; Mortality; Stress hyperglycemia
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Substance Nomenclature:
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0 (Glycated Hemoglobin A)
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Entry Date(s):
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Date Created: 20181009 Date Completed: 20190916 Latest Revision: 20221207
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Update Code:
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20240104
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DOI:
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10.1016/j.endinu.2018.07.005
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PMID:
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30293899
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Introduction: The study objective was to estimate during post-discharge follow-up the incidence of diabetes and to ascertain mortality in hospitalized patients, classified during follow-up as having stress hyperglycemia (SH) or normoglycemia (NG) based on blood glucose levels.
Material and Methods: A retrospective cohort of non-diabetic adults with SH (> 140mg/dl and HbA1c <6.5%) or NG (all blood glucose values ≤ 140mg/dl) was used.
Results: There were 3981 patients with NG and 884 with SH. During the observation period (median follow-up of 1.83 years), there were 255 cases of diabetes and 831 deaths. The cumulative incidence of diabetes per year was 1.59% (95% CI: 1.23-2.06) in patients with NG and 7.39% (95% CI: 5.70-9.56) in those with SH. SH was significantly associated to diabetes (crude HR 1.33, 95% CI: 1.13-1.73, p .025), even after adjusting for age and sex (adjusted HR 1.38, 95% CI 1.06-1.78, p .014). The mortality rate at one year was 10.07% (95% CI: 9.18-11.05) in NG patients and 13.24% (95% CI: 11.17-15.65) in SH patients. The sub-hazard ratio of developing diabetes considering death as a competitive event was 1.41 (95% CI 1.29-1.53, p <.001).
Conclusions: SH is a risk factor for diabetes. There were no differences in mortality during follow-up, but death appears to be a competitive event in development of diabetes in this population.
(Copyright © 2018 SEEN y SED. Publicado por Elsevier España, S.L.U. All rights reserved.)
