Circadian disruption favors alcohol consumption and differential ΔFosB accumulation in Corticolimbic structures.

Szczegóły
Abstrakt

Tytuł:: Circadian disruption favors alcohol consumption and differential ΔFosB accumulation in Corticolimbic structures.
Autorzy:: Reséndiz-Flores M; Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico.
Escobar C; Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico.
Źródło:: Addiction biology [Addict Biol] 2019 Nov; Vol. 24 (6), pp. 1179-1190. Date of Electronic Publication: 2018 Oct 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: Hoboken, NJ : Wiley-Blackwell
Original Publication: Abingdon, Oxfordshire, UK ; Cambridge, MA : Carfax, c1996-
MeSH Terms:: Alcohol Drinking*
Circadian Rhythm*
Shift Work Schedule*
Brain/*drug effects
Central Nervous System Depressants/*pharmacology
Ethanol/*pharmacology
Proto-Oncogene Proteins c-fos/*drug effects
Animals ; Anxiety/metabolism ; Behavior, Animal ; Brain/metabolism ; Central Amygdaloid Nucleus/drug effects ; Central Amygdaloid Nucleus/metabolism ; Central Nervous System Depressants/administration & dosage ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; Ethanol/administration & dosage ; Neuronal Plasticity ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Period Circadian Proteins/metabolism ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; Proto-Oncogene Proteins c-fos/metabolism ; Random Allocation ; Rats ; Self Administration ; Stress, Psychological/metabolism ; Suprachiasmatic Nucleus/drug effects ; Suprachiasmatic Nucleus/metabolism
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Grant Information:: IG-200417 International DGAPA-PAPIIT; 239403 International CONACyT
Contributed Indexing:: Keywords: accumbens; alcohol; binge; circadian disruption; ΔFosB
Substance Nomenclature:: 0 (Central Nervous System Depressants)
0 (Fosb protein, rat)
0 (Per1 protein, rat)
0 (Period Circadian Proteins)
0 (Proto-Oncogene Proteins c-fos)
3K9958V90M (Ethanol)
Entry Date(s):: Date Created: 20181009 Date Completed: 20201028 Latest Revision: 20201028
Update Code:: 20240104
DOI:: 10.1111/adb.12674
PMID:: 30295391
: Czasopismo naukowe

Pełny tekst

Shift-work and exposure to light at night lead to circadian disruption, which favors the use of alcohol and may be a risk factor for development of addictive behavior. This study evaluated in two experimental models of circadian disruption behavioral indicators of elevated alcohol intake and looked for ΔFosB, which is a transcription factor for neuronal plasticity in corticolimbic structures. Male Wistar rats were exposed to experimental shift-work (AR) or to constant light (LL) and were compared with a control group (LD). After 4 weeks in their corresponding conditions, control LD rats remained rhythmic, AR rats exhibited a loss of day-night patterns in the brain and the LL rats showed arrhythmicity in general activity and day-night PER1 patterns in corticolimbic structures. During 12 days of exposure to 10 percent alcohol solution, the AR group showed daily increased alcohol intake while LD and LL rats ingested similar amounts. After 72 h of alcohol deprivation, AR and LL rats increased alcohol intake in a binge-like test; this could be due not only to circadian disruption but also to stress and/or anxiety developed from the AR and LL manipulations. Associated to the increased alcohol intake, the AR and LL rats had significant accumulation of ΔFosB in the nucleus accumbens shell and decreased ΔFosB in the infralimbic cortex. Data here reported confirm that the disruption of temporal patterns favors the increased alcohol consumption and that this is associated with a differential accumulation of ΔFosB which may favor the development of addictive behavior.
(© 2018 Society for the Study of Addiction.)

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