Prescription Opioid Analgesics Increase Risk of Major Depression: New Evidence, Plausible Neurobiological Mechanisms and Management to Achieve Depression Prophylaxis.

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Tytuł:: Prescription Opioid Analgesics Increase Risk of Major Depression: New Evidence, Plausible Neurobiological Mechanisms and Management to Achieve Depression Prophylaxis.
Autorzy:: Semenkovich K; Katherine Semenkovich, BA, is in the Department of Pediatrics at Washington University School of Medicine.
Chockalingam R; Ravikumar Chockalingam, MD, Department of Psychiatry at Washington University School of Medicine.
Scherrer JF; Jeffrey F. Scherrer, PhD, is in Research Service, John Cochran Hospital, St. Louis VA Medical Center.
Panagopoulos VN; Vassilis N. Panagopoulos, MD, Bell Street Clinic Opioid Treatment Program and at the at the Washington University School of Medicine and the Veterans Administration Medical Center in St. Louis.
Lustman PJ; Patrick J. Lustman, PhD, Bell Street Clinic Opioid Treatment Program and at the at the Washington University School of Medicine and the Veterans Administration Medical Center in St. Louis.
Ray JM; John M. Ray, MA, is in Mental Health Service, St. Louis VA Medical Center.
Freedland KE; Kenneth E. Freedland, PhD, Department of Psychiatry at Washington University School of Medicine.
Svrakic DM; Dragan M. Svrakic, MD, PhD, Bell Street Clinic Opioid Treatment Program and at the at the Washington University School of Medicine and the Veterans Administration Medical Center in St. Louis.
Źródło:: Missouri medicine [Mo Med] 2014 Mar-Apr; Vol. 111 (2), pp. 148-154.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Jefferson City Mo : Missouri State Medical Association
Original Publication: St. Louis.
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Entry Date(s):: Date Created: 20181017 Latest Revision: 20191120
Update Code:: 20240105
PubMed Central ID:: PMC6179498
PMID:: 30323529
: Czasopismo naukowe

More than 200 million prescriptions are written annually for opioid analgesics despite limited evidence of their long-term efficacy. These medications currently are prescribed to 10% - 15% of Americans with use of long-acting opioids projected to double in the next three to four years. Despite this widespread use, little is known about the risks of opioids, particularly with chronic use. New data from our research group published in the Journal of General Internal Medicine provides clear evidence that prescription opioid used for non-cancer, non-HIV pain increases significantly the risk of development of major depressive disorder in opioid naïve individuals with no recent history of depression and substance used disorders. The risk of depression increased as the dose and/or the duration of opioid use increased. The purpose of the present paper is to elucidate the details of this study, to examine potential neurobiological mechanisms responsible for the depressogenic effect of opioid analgesics, and to discuss management options that emphasize depression prophylaxis.

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