Urine 4-(methylnitrosamino)-1-(3) pyridyl-1-butanol and cotinine in Alaska native postpartum women and neonates comparing smokers and smokeless tobacco users.

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Tytuł:: Urine 4-(methylnitrosamino)-1-(3) pyridyl-1-butanol and cotinine in Alaska native postpartum women and neonates comparing smokers and smokeless tobacco users.
Autorzy:: Benowitz NL; a Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, Departments of Medicine and Bioengineering & Therapeutic Sciences , University of California , San Francisco , California , USA.; b Center for Tobacco Control Research and Education , University of California , San Francisco , California , USA.
Flanagan CA; c Alaska Native Tribal Health Consortium , Anchorage , AK , USA.
Thomas TK; c Alaska Native Tribal Health Consortium , Anchorage , AK , USA.
Koller KR; c Alaska Native Tribal Health Consortium , Anchorage , AK , USA.
Wolfe AW; c Alaska Native Tribal Health Consortium , Anchorage , AK , USA.
Renner CC; c Alaska Native Tribal Health Consortium , Anchorage , AK , USA.
Hughes C; d Mayo Clinic , Rochester , MN , USA.
Decker PA; d Mayo Clinic , Rochester , MN , USA.
Hatsukami DK; e University of Minnesota , Minneapolis , MN , USA.
Murphy NJ; f Department of Obstetrics and Gynecology, Alaska Native Medical Center , Southcentral Foundation , Anchorage , AK , USA.
Patten C; d Mayo Clinic , Rochester , MN , USA.
Źródło:: International journal of circumpolar health [Int J Circumpolar Health] 2018 Dec; Vol. 77 (1), pp. 1528125.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
Język:: English
Imprint Name(s):: Publication: 2016- : Philadelphia, PA : Taylor & Francis
Original Publication: Oulu, Finland : International Union for Circumpolar Health and the Nordic Society of Arctic Medicine, [1997-
MeSH Terms:: Alaska Natives*
Cotinine/*urine
Nitrosamines/*urine
Prenatal Exposure Delayed Effects/*urine
Tobacco Use/*ethnology
Tobacco Use/*urine
Adult ; Alaska/epidemiology ; Arctic Regions/epidemiology ; Biomarkers ; Female ; Humans ; Infant, Newborn ; Postpartum Period ; Pregnancy ; Socioeconomic Factors ; Tobacco Smoking/urine ; Tobacco, Smokeless/analysis ; Young Adult
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Grant Information:: P30 DA012393 United States DA NIDA NIH HHS; U54 CA153605 United States CA NCI NIH HHS
Contributed Indexing:: Keywords: Biomarkers; carcinogens; cigarette smoking; neonate; pregnancy
Substance Nomenclature:: 0 (Biomarkers)
0 (Nitrosamines)
EN7PIX794W (4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol)
K5161X06LL (Cotinine)
Entry Date(s):: Date Created: 20181017 Date Completed: 20190409 Latest Revision: 20240109
Update Code:: 20240109
PubMed Central ID:: PMC6197029
DOI:: 10.1080/22423982.2018.1528125
PMID:: 30325719
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Objective: Foetuses and neonates of women who use tobacco are exposed to nicotine and tobacco-derived carcinogens. We determined the relationship between urine biomarkers of tobacco toxicant exposure postpartum and in the neonates of Alaska Native (AN) women, comparing smokers and smokeless tobacco (ST) users, including iqmik, a homemade ST product.
Methods: AN women, including 36 smokers, 9 commercial ST and 16 iqmik users their neonates participated. Urine from the woman at the time of delivery and her neonate's first urine were analysed for cotinine, the major metabolite of nicotine, and 4-(methylnitrosamino)-1-(3) pyridyl-1-butanol (NNAL), a tobacco-specific carcinogen biomarker.
Results: Maternal urine cotinine and neonatal urine cotinine were strongly correlated in all tobacco use groups (r from 0.83 to 0.9, p < 0.002). Correlations between maternal cotinine and neonatal NNAL were moderately strong for cigarettes and commercial smokeless but weaker for iqmik users (r 0.73, 0.6 and 0.36, respectively).
Conclusion: Correlations between maternal and neonatal biomarkers of tobacco toxicant exposure vary, dependent on tobacco product use.
Significance: This study provides novel data on biomarkers of tobacco exposure among postpartum AN women and their neonates. The results could be useful to guide future epidemiological studies of health risks associated with use of various tobacco products during pregnancy.

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