Vti1b promotes TRPV1 sensitization during inflammatory pain.

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Abstrakt

Tytuł:: Vti1b promotes TRPV1 sensitization during inflammatory pain.
Autorzy:: Sondermann JR; Somatosensory Signaling and Systems Biology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany. Ms. Barry is now with Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Ms. Abdelaziz is now with Oncophysiology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany.
Barry AM; Somatosensory Signaling and Systems Biology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany. Ms. Barry is now with Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Ms. Abdelaziz is now with Oncophysiology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany.
Jahn O; Proteomics Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany.
Michel N; Somatosensory Signaling and Systems Biology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany. Ms. Barry is now with Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Ms. Abdelaziz is now with Oncophysiology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany.
Abdelaziz R; Somatosensory Signaling and Systems Biology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany. Ms. Barry is now with Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Ms. Abdelaziz is now with Oncophysiology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany.
Kügler S; Department of Neurology, University Medical Center Goettingen, Goettingen, Germany.
Gomez-Varela D; Somatosensory Signaling and Systems Biology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany. Ms. Barry is now with Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Ms. Abdelaziz is now with Oncophysiology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany.
Schmidt M; Somatosensory Signaling and Systems Biology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany. Ms. Barry is now with Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Ms. Abdelaziz is now with Oncophysiology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany.
Źródło:: Pain [Pain] 2019 Feb; Vol. 160 (2), pp. 508-527.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2015- : Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Amsterdam, Elsevier/North-Holland.
MeSH Terms:: Gene Expression Regulation/*genetics
Hyperalgesia/*genetics
Pain/*metabolism
Qb-SNARE Proteins/*metabolism
TRPV Cation Channels/*metabolism
Animals ; Calcium/metabolism ; Capsaicin/pharmacology ; Cells, Cultured ; Disease Models, Animal ; Freund's Adjuvant/toxicity ; Ganglia, Spinal/cytology ; Humans ; Hyperalgesia/physiopathology ; Inflammation/chemically induced ; Inflammation/complications ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Pain/etiology ; Qb-SNARE Proteins/genetics ; RNA Interference/physiology ; Sensory Receptor Cells/drug effects ; Sensory Receptor Cells/physiology ; Signal Transduction ; TRPV Cation Channels/genetics
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Substance Nomenclature:: 0 (Qb-SNARE Proteins)
0 (TRPV Cation Channels)
0 (TRPV1 protein, mouse)
0 (Vti1b protein, mouse)
9007-81-2 (Freund's Adjuvant)
S07O44R1ZM (Capsaicin)
SY7Q814VUP (Calcium)
Entry Date(s):: Date Created: 20181019 Date Completed: 20190626 Latest Revision: 20210114
Update Code:: 20240105
DOI:: 10.1097/j.pain.0000000000001418
PMID:: 30335684
: Czasopismo naukowe

Sensitization of the transient receptor potential ion channel vanilloid 1 (TRPV1) is critically involved in inflammatory pain. To date, manifold signaling cascades have been shown to converge onto TRPV1 and enhance its sensitization. However, many of them also play a role for nociceptive pain, which limits their utility as targets for therapeutic intervention. Here, we show that the vesicle transport through interaction with t-SNAREs homolog 1B (Vti1b) protein promotes TRPV1 sensitization upon inflammation in cell culture but leaves normal functioning of TRPV1 intact. Importantly, the effect of Vti1b can be recapitulated in vivo: Virus-mediated knockdown of Vti1b in sensory neurons attenuated thermal hypersensitivity during inflammatory pain without affecting mechanical hypersensitivity or capsaicin-induced nociceptive pain. Interestingly, TRPV1 and Vti1b are localized in close vicinity as indicated by proximity ligation assays and are likely to bind to each other, either directly or indirectly, as suggested by coimmunoprecipitations. Moreover, using a mass spectrometry-based quantitative interactomics approach, we show that Vti1b is less abundant in TRPV1 protein complexes during inflammatory conditions compared with controls. Alongside, we identify numerous novel and pain state-dependent binding partners of native TRPV1 in dorsal root ganglia. These data represent a unique resource on the dynamics of the TRPV1 interactome and facilitate mechanistic insights into TRPV1 regulation. We propose that inflammation-related differences in the TRPV1 interactome identified here could be exploited to specifically target inflammatory pain in the future.

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