Sensory attenuation in Parkinson's disease is related to disease severity and dopamine dose.

Tytuł:: Sensory attenuation in Parkinson's disease is related to disease severity and dopamine dose.
Autorzy:: Wolpe N; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0SZ, UK. .; Medical Research Council Cognition and Brain Sciences Unit, Cambridge, CB2 7EF, UK. .; Cambridge Centre for Ageing and Neuroscience, University of Cambridge and MRC Cognition and Brain Sciences Unit, Cambridge, CB2 3EB, UK. .
Zhang J; Medical Research Council Cognition and Brain Sciences Unit, Cambridge, CB2 7EF, UK.; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, CF24 4HQ, UK.
Nombela C; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0SZ, UK.; Medical Research Council Cognition and Brain Sciences Unit, Cambridge, CB2 7EF, UK.
Ingram JN; Cambridge Centre for Ageing and Neuroscience, University of Cambridge and MRC Cognition and Brain Sciences Unit, Cambridge, CB2 3EB, UK.; Computational and Biological Learning Laboratory, Department of Engineering, University of Cambridge, Cambridge, CB2 1PZ, UK.; Zuckerman Mind Brain Behavior Institute, Department of Neuroscience, Columbia University, New York, United States.
Wolpert DM; Cambridge Centre for Ageing and Neuroscience, University of Cambridge and MRC Cognition and Brain Sciences Unit, Cambridge, CB2 3EB, UK.; Computational and Biological Learning Laboratory, Department of Engineering, University of Cambridge, Cambridge, CB2 1PZ, UK.; Zuckerman Mind Brain Behavior Institute, Department of Neuroscience, Columbia University, New York, United States.
Rowe JB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0SZ, UK.; Medical Research Council Cognition and Brain Sciences Unit, Cambridge, CB2 7EF, UK.; Cambridge Centre for Ageing and Neuroscience, University of Cambridge and MRC Cognition and Brain Sciences Unit, Cambridge, CB2 3EB, UK.
Corporate Authors:: Cam-CAN
Źródło:: Scientific reports [Sci Rep] 2018 Oct 23; Vol. 8 (1), pp. 15643. Date of Electronic Publication: 2018 Oct 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:: Sensation*
Severity of Illness Index*
Dopamine/*metabolism
Parkinson Disease/*pathology
Parkinson Disease/*physiopathology
Aged ; Aged, 80 and over ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Task Performance and Analysis
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Grant Information:: MC_UU_00005/12 United Kingdom MRC_ Medical Research Council; 097803 United Kingdom WT_ Wellcome Trust; BB/H008217/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; SUAG/004 RG91365 United Kingdom MRC_ Medical Research Council; 103838 United Kingdom Wellcome Trust; MC_U105597119 United Kingdom MRC_ Medical Research Council; United Kingdom Wellcome Trust
Contributed Indexing:: Investigator: LK Tyler; C Brayne; ET Bullmore; AC Calder; R Cusack; T Dalgleish; J Duncan; FE Matthews; WD Marslen-Wilson; MA Shafto; T Cheung; L Geerligs; A McCarrey; A Mustafa; D Price; D Samu; M Treder; KA Tsvetanov; J van Belle; N Williams; L Bates; A Gadie; S Gerbase; S Georgieva; C Hanley; B Parkin; D Troy; T Auer; M Correia; L Gao; E Green; R Henriques; J Allen; G Amery; L Amunts; A Barcroft; A Castle; C Dias; J Dowrick; M Fair; H Fisher; A Goulding; A Grewal; G Hale; A Hilton; F Johnson; P Johnston; T Kavanagh-Williamson; M Kwasniewska; A McMinn; K Norman; J Penrose; F Roby; D Rowland; J Sargeant; M Squire; B Stevens; A Stoddart; C Stone; T Thompson; O Yazlik; Dan Barnes; M Dixon; J Hillman; J Mitchell; L Villis
Substance Nomenclature:: VTD58H1Z2X (Dopamine)
Entry Date(s):: Date Created: 20181025 Date Completed: 20191119 Latest Revision: 20240403
Update Code:: 20240403
PubMed Central ID:: PMC6199336
DOI:: 10.1038/s41598-018-33678-3
PMID:: 30353104
: Czasopismo naukowe

Pełny tekst

Abnormal initiation and control of voluntary movements are among the principal manifestations of Parkinson's disease (PD). However, the processes underlying these abnormalities and their potential remediation by dopamine treatment remain poorly understood. Normally, movements depend on the integration of sensory information with the predicted consequences of action. This integration leads to a suppression in the intensity of predicted sensations, reflected in a 'sensory attenuation'. We examined this integration process and its relation to dopamine in PD, by measuring sensory attenuation. Patients with idiopathic PD (n = 18) and population-derived controls (n = 175) matched a set of target forces applied to their left index finger by a torque motor. To match the force, participants either pressed with their right index finger ('Direct' condition) or moved a knob that controlled a motor through a linear potentiometer ('Slider' condition). We found that despite changes in sensitivity to different forces, overall sensory attenuation did not differ between medicated PD patients and controls. Importantly, the degree of attenuation was negatively related to PD motor severity but positively related to individual patient dopamine dose, as measured by levodopa dose equivalent. The results suggest that dopamine could regulate the integration of sensorimotor prediction with sensory information to facilitate the control of voluntary movements.

Erratum in: Sci Rep. 2018 Nov 22;8(1):17429. (PMID: 30467360)

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