Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful?

Tytuł:
Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful?
Autorzy:
Assadiasl S; Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mousavi MJ; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.; Department of Hematology, Faculty of Allied Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
Amirzargar A; Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Źródło:
Journal of transplantation [J Transplant] 2018 Oct 01; Vol. 2018, pp. 6492034. Date of Electronic Publication: 2018 Oct 01 (Print Publication: 2018).
Typ publikacji:
Journal Article; Review
Język:
English
Imprint Name(s):
Original Publication: [New York, NY] : Hindawi Pub. Corp.
References:
Int J Cancer. 2013 Nov 15;133(10):2341-50. (PMID: 23640782)
Blood. 2007 Jun 1;109(11):4742-52. (PMID: 17299096)
J Exp Med. 2004 Jan 5;199(1):69-80. (PMID: 14699085)
Kidney Int. 2011 Jul;80(1):29-40. (PMID: 21562469)
Hum Immunol. 2002 Feb;63(2):101-7. (PMID: 11821157)
Mol Cancer. 2015 Nov 19;14:198. (PMID: 26584646)
Mol Cell. 2000 Jul;6(1):183-9. (PMID: 10949039)
Biochem Biophys Res Commun. 2002 Sep 13;297(1):59-64. (PMID: 12220508)
Eur J Heart Fail. 2009 Nov;11(11):1023-30. (PMID: 19875403)
J Immunol. 2016 Mar 1;196(5):2195-204. (PMID: 26810226)
Hum Pathol. 2001 Jan;32(1):119-25. (PMID: 11172305)
Bioconjug Chem. 2013 Dec 18;24(12):2036-44. (PMID: 24256337)
Lab Invest. 1999 Nov;79(11):1327-33. (PMID: 10576203)
Am J Transplant. 2014 May;14(5):1046-60. (PMID: 24731002)
Indian J Med Res. 2015 Apr;141(4):389-97. (PMID: 26112839)
Trends Mol Med. 2001 Dec;7(12):542-7. (PMID: 11733216)
EMBO Rep. 2006 Apr;7(4):438-43. (PMID: 16470228)
Biomarkers. 2015;20(3):177-82. (PMID: 26155824)
PLoS One. 2009 Dec 11;4(12):e8244. (PMID: 20011512)
J Transl Med. 2011 Jul 06;9:105. (PMID: 21733181)
Lab Invest. 1999 Sep;79(9):1121-6. (PMID: 10496530)
Am J Pathol. 2007 Nov;171(5):1483-98. (PMID: 17982126)
J Biol Chem. 2002 Feb 1;277(5):3247-57. (PMID: 11714700)
Mol Hum Reprod. 2000 Jun;6(6):529-34. (PMID: 10825370)
J Exp Med. 2007 Jul 9;204(7):1603-11. (PMID: 17576776)
Stem Cells. 2018 Jan;36(1):123-129. (PMID: 29067757)
Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11480-5. (PMID: 16055565)
Immunity. 2005 May;22(5):621-31. (PMID: 15894279)
Nat Med. 1997 Aug;3(8):917-21. (PMID: 9256286)
Yonsei Med J. 2014 Jul;55(4):1130-7. (PMID: 24954347)
FASEB J. 2008 Feb;22(2):510-21. (PMID: 17804696)
J Am Soc Nephrol. 2013 Dec;24(12):2023-33. (PMID: 23949800)
Entry Date(s):
Date Created: 20181027 Latest Revision: 20201001
Update Code:
20240105
PubMed Central ID:
PMC6188762
DOI:
10.1155/2018/6492034
PMID:
30364092
Czasopismo naukowe
Survivin, an antiapoptotic molecule from inhibitor of apoptosis protein (IAP) family, is most known for its implication in cancer as there are some efforts to apply it for diagnostic as well as therapeutic purposes in oncology. On the other hand, it could be a useful molecule to be positively targeted when trying to save tissue and promote cells viability. Since protecting the allograft from ischemia reperfusion injury and inflammation-induced damage is a considerable objective in transplantation, it is reasonable to take advantage from antiapoptotic agents like survivin in order to achieve this goal. However, survivin's potential ability to induce malignancies makes some concerns about its use in clinic. The other barrier is this molecule's involvement in lymphocytes development and proliferation which might increase the risk of graft rejection due to adaptive immune system overactivation. In this review we summarize the few studies carried out about survivin's effect on graft survival and probable advantages and disadvantages of its overexpression in transplantation.
Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies