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Tytuł pozycji:

Changes in recruitment of motor cortex excitation and inhibition in patients with drug-induced tardive syndromes.

Tytuł :
Changes in recruitment of motor cortex excitation and inhibition in patients with drug-induced tardive syndromes.
Autorzy :
Khedr EM; Department of Neuropsychiatry, Faculty of Medicine, Assiut University, Assiut, Egypt; Department of Neuropsychiatry, Faculty of Medicine, Aswan University, Aswan, Egypt. Electronic address: .
Al Fawal B; Department of Neuropsychiatry, Faculty of Medicine, Aswan University, Aswan, Egypt.
Abdelwarith AM; Department of Neuropsychiatry, Faculty of Medicine, Aswan University, Aswan, Egypt.
Saber M; Department of Neuropsychiatry, Faculty of Medicine, Aswan University, Aswan, Egypt.
Tony AAH; Department of Neuropsychiatry, Faculty of Medicine, Aswan University, Aswan, Egypt.
El-Bassiony A; Department of Neuropsychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Rothwell JC; Sobell Department of Motor Neuroscience and movement Disorders, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
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Źródło :
Neurophysiologie clinique = Clinical neurophysiology [Neurophysiol Clin] 2019 Feb; Vol. 49 (1), pp. 33-40. Date of Electronic Publication: 2018 Oct 23.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: Paris : Elsevier
Original Publication: Amsterdam ; New York : Elsevier, c1988-
MeSH Terms :
Cortical Excitability/*physiology
Evoked Potentials, Motor/*physiology
Motor Cortex/*physiopathology
Neural Inhibition/*physiology
Adult ; Cortical Excitability/drug effects ; Evoked Potentials, Motor/drug effects ; Female ; Humans ; Male ; Middle Aged ; Motor Cortex/drug effects ; Neural Inhibition/drug effects ; Syndrome ; Transcranial Magnetic Stimulation/methods ; Young Adult
Contributed Indexing :
Keywords: Contralateral cortical silent period; Cortical excitability; Drug-induced extrapyramidal; Input–output curve; Motor threshold; Tardive dyskinesia; Tardive syndrome; Transcallosal inhibition; Transcranial magnetic stimulation
Entry Date(s) :
Date Created: 20181028 Date Completed: 20190404 Latest Revision: 20190404
Update Code :
20210623
DOI :
10.1016/j.neucli.2018.10.001
PMID :
30366858
Czasopismo naukowe
Objectives: It has recently been suggested that drug-induced tardive syndromes (TS) might be due to maladaptive plasticity, which increases motor excitability in cerebral cortex and basal ganglia. In order to test this hypothesis, we performed the first measurements of cortical excitability in TS.
Methods: Motor cortex excitability was examined using transcranial magnetic stimulation (TMS) in 22 TS patients and compared with that in 20 age and sex-matched healthy individuals. Resting and active motor threshold (RMT, AMT) and input-output curves (I/O curves) assessed corticospinal excitability. The duration of the contralateral silent period (cSP) at a range of stimulation intensities and ipsilateral silent period (iSP) were used as measures of inhibition.
Results: There were no significant differences in RMT and AMT between patients and controls, although the input-output curves were significantly steeper in patients. The cSP (at different stimulus intensities) and iSP were both longer in the patients compared to the control group. However, most of this difference could be accounted for by increased recruitment of motor evoked potentials (MEPs) in patients.
Conclusion: TS is characterized by hyperexcitability of corticospinal output that might contribute to the lack of selectivity in muscle recruitment and contribute to excess involuntary movement. The findings are opposite to those in naturally-occurring hyperkinesia such as Sydenham's and Huntington's chorea, suggesting a fundamental difference in the pathophysiology.
(Crown Copyright © 2018. Published by Elsevier Masson SAS. All rights reserved.)

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