Overexpression of ASIC1A in the nucleus accumbens of rats potentiates cocaine-seeking behavior.

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Abstrakt

Tytuł:: Overexpression of ASIC1A in the nucleus accumbens of rats potentiates cocaine-seeking behavior.
Autorzy:: Gutman AL; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA.
Cosme CV; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA.
Noterman MF; Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA, USA.
Worth WR; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA.
Wemmie JA; Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA, USA.; Department of Psychiatry, University of Iowa, Iowa City, IA, USA.; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA.
LaLumiere RT; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA.; Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA, USA.; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA.
Źródło:: Addiction biology [Addict Biol] 2020 Mar; Vol. 25 (2), pp. e12690. Date of Electronic Publication: 2018 Nov 06.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
Język:: English
Imprint Name(s):: Publication: Hoboken, NJ : Wiley-Blackwell
Original Publication: Abingdon, Oxfordshire, UK ; Cambridge, MA : Carfax, c1996-
MeSH Terms:: Acid Sensing Ion Channels/*genetics
Behavior, Animal/*drug effects
Cocaine/*pharmacology
Cocaine-Related Disorders/*genetics
Gene Expression/*genetics
Nucleus Accumbens/*drug effects
Animals ; Cocaine-Related Disorders/physiopathology ; Disease Models, Animal ; Dopamine Uptake Inhibitors/pharmacology ; Male ; Nucleus Accumbens/physiopathology ; Rats ; Rats, Sprague-Dawley
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Grant Information:: R01 DA034684 United States DA NIDA NIH HHS; DA034684 International National Institutes of Health/National Institute on Drug Abuse; R01 MH113325 United States MH NIMH NIH HHS; DA043364-01 International National Institutes of Health/National Institute on Drug Abuse; F31 DA043364 United States DA NIDA NIH HHS; R01 DA037216 United States DA NIDA NIH HHS; DA037216 International National Institutes of Health/National Institute on Drug Abuse
Contributed Indexing:: Keywords: abstinence; incubation; reinstatement; self-administration; withdrawal
Substance Nomenclature:: 0 (Acid Sensing Ion Channels)
0 (Asic1 protein, rat)
0 (Dopamine Uptake Inhibitors)
I5Y540LHVR (Cocaine)
Entry Date(s):: Date Created: 20181107 Date Completed: 20210216 Latest Revision: 20230916
Update Code:: 20240104
PubMed Central ID:: PMC9092352
DOI:: 10.1111/adb.12690
PMID:: 30397978
: Czasopismo naukowe

Pełny tekst

Acid-sensing ion channels (ASICs) are abundantly expressed in the nucleus accumbens core (NAcore), a region of the mesolimbocortical system that has an established role in regulating drug-seeking behavior. Previous work shows that a single dose of cocaine reduced the AMPA-to-NMDA ratio in Asic1a -/- mice, an effect observed after withdrawal in wild-type mice, whereas ASIC1A overexpression in the NAcore of rats decreases cocaine self-administration. However, whether ASIC1A overexpression in the NAcore alters measures of drug-seeking behavior after the self-administration period is unknown. To examine this issue, the ASIC1A subunit was overexpressed in male Sprague-Dawley rats by injecting them with adeno-associated virus, targeted at the NAcore, after completion of 2 weeks of cocaine or food self-administration. After 21 days of homecage abstinence, rats underwent a cue-/context-driven drug/food-seeking test, followed by extinction training and then drug/food-primed, cued, and cued + drug/food-primed reinstatement tests. The results indicate that ASIC1A overexpression in the NAcore enhanced cue-/context-driven cocaine seeking, cocaine-primed reinstatement, and cued + cocaine-primed reinstatement but had no effect on food-seeking behavior, indicating a selective effect for ASIC1A in the processes underlying extinction and cocaine-seeking behavior.
(© 2018 Society for the Study of Addiction.)

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