Sex Hormones and Measures of Kidney Function in the Diabetes Prevention Program Outcomes Study.

Szczegóły
Abstrakt

Tytuł:: Sex Hormones and Measures of Kidney Function in the Diabetes Prevention Program Outcomes Study.
Autorzy:: Kim C; Departments of Medicine, Obstetrics & Gynecology, and Epidemiology, University of Michigan, Ann Arbor, Michigan.
Ricardo AC; Department of Medicine, University of Illinois, Chicago, Illinois.
Boyko EJ; Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington.
Christophi CA; Biostatistics Center, George Washington University, Rockville, Maryland.
Temprosa M; Biostatistics Center, George Washington University, Rockville, Maryland.; Department of Epidemiology & Biostatistics, George Washington University, Washington, DC.
Watson KE; Department of Medicine, University of California, Los Angeles, California.
Pi-Sunyer X; Department of Medicine, Columbia University College of Physicians and Surgeons, New York City, New York.
Kalyani RR; Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
Corporate Authors:: Diabetes Prevention Program Research Group
Źródło:: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2019 Apr 01; Vol. 104 (4), pp. 1171-1180.
Typ publikacji:: Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
Język:: English
Imprint Name(s):: Publication: 2017- : New York : Oxford University Press
Original Publication: Springfield, Ill. : Charles C. Thomas
MeSH Terms:: Glomerular Filtration Rate*
Albuminuria/*epidemiology
Diabetic Nephropathies/*epidemiology
Estradiol/*blood
Sex Hormone-Binding Globulin/*analysis
Adult ; Albuminuria/blood ; Albuminuria/urine ; Creatinine/urine ; Cross-Sectional Studies ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/etiology ; Diabetes Mellitus/prevention & control ; Diabetic Nephropathies/blood ; Diabetic Nephropathies/etiology ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Incidence ; Kidney Function Tests ; Male ; Middle Aged ; Overweight/complications ; Sex Factors
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Grant Information:: R01 DK072041 United States DK NIDDK NIH HHS; K23 DK094829 United States DK NIDDK NIH HHS; U01 DK048489 United States DK NIDDK NIH HHS; R01 DK053061 United States DK NIDDK NIH HHS; P30 DK017047 United States DK NIDDK NIH HHS; P30 DK020572 United States DK NIDDK NIH HHS; P30 DK026687 United States DK NIDDK NIH HHS
Molecular Sequence:: ClinicalTrials.gov NCT00038727
Substance Nomenclature:: 0 (SHBG protein, human)
0 (Sex Hormone-Binding Globulin)
4TI98Z838E (Estradiol)
AYI8EX34EU (Creatinine)
Entry Date(s):: Date Created: 20181107 Date Completed: 20200127 Latest Revision: 20200624
Update Code:: 20240104
PubMed Central ID:: PMC6391355
DOI:: 10.1210/jc.2018-01495
PMID:: 30398516
: Czasopismo naukowe

Context: Despite sex differences in chronic kidney disease (CKD) onset and progression, it is unclear whether endogenous sex hormones are associated with kidney function in persons without CKD.
Design and Methods: We conducted a secondary analysis of the Diabetes Prevention Program (DPP) and its follow-up observational study, the DPP Outcomes Study, over 11 years. Participants included overweight and glucose-intolerant men (n = 889) and pre- and postmenopausal women (n = 1281) not using exogenous sex hormones and whose urine albumin-to-creatinine ratio (ACR) was <30 mg/g and normal estimated glomerular filtration ratio (eGFR) was ≥60 mL/min/1.73 m2 at randomization. We examined the association between sex hormone levels and incidence of low eGFR and/or ACR ≥30 mg/g on at least one measurement.
Results: At randomization, the mean (SD) eGFR was 94 (15) mL/min/1.73 m2; the median ACR (interquartile range) was 4.5 (3.3 to 7.6) mg/g. During follow-up, 187 men (24.6%) and 263 women (24.2%) had incident albuminuria and 136 men (17.9%) and 123 women (11.3%) had incident low eGFR. Among men, higher baseline sex hormone-binding globulin (SHBG) level was associated with reduced low eGFR risk (hazard ratio per SD, 0.80; 95% CI, 0.57 to 0.90) in adjusted analyses. No significant associations were observed among women. There were significant interactions between sex steroid levels and low eGFR by randomization arm.
Conclusion: Sex steroids were not associated with development of low eGFR or albuminuria. Among men, higher SHBG level was associated with reduced risk of low eGFR on at least one measurement.
(Copyright © 2019 Endocrine Society.)

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