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Tytuł pozycji:

Activation of trigeminal ganglion satellite glial cells in CFA-induced tooth pulp pain in rats.

Tytuł:
Activation of trigeminal ganglion satellite glial cells in CFA-induced tooth pulp pain in rats.
Autorzy:
Filippini HF; Programa de Pós-graduação em Odontologia, Escola de Ciências da Saúde, PUCRS, Porto Alegre, RS, Brasil.
Scalzilli PA; Laboratório de Patologia, Escola de Ciência da Saúde, PUCRS, Porto Alegre, RS, Brasil.; Centro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde, PUCRS, Porto Alegre, RS, Brasil.
Costa KM; Programa de Pós-graduação em Medicina e Ciências da Saúde, Escola de Medicina, PUCRS, Porto Alegre, RS, Brasil.
Freitas RDS; Centro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde, PUCRS, Porto Alegre, RS, Brasil.; Programa de Pós-graduação em Medicina e Ciências da Saúde, Escola de Medicina, PUCRS, Porto Alegre, RS, Brasil.
Campos MM; Programa de Pós-graduação em Odontologia, Escola de Ciências da Saúde, PUCRS, Porto Alegre, RS, Brasil.; Laboratório de Patologia, Escola de Ciência da Saúde, PUCRS, Porto Alegre, RS, Brasil.; Centro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde, PUCRS, Porto Alegre, RS, Brasil.; Programa de Pós-graduação em Medicina e Ciências da Saúde, Escola de Medicina, PUCRS, Porto Alegre, RS, Brasil.
Źródło:
PloS one [PLoS One] 2018 Nov 12; Vol. 13 (11), pp. e0207411. Date of Electronic Publication: 2018 Nov 12 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms:
Dental Pulp*/metabolism
Dental Pulp*/pathology
Dental Pulp*/physiopathology
Satellite Cells, Perineuronal*/metabolism
Satellite Cells, Perineuronal*/pathology
Toothache*/chemically induced
Toothache*/metabolism
Toothache*/pathology
Toothache*/physiopathology
Trigeminal Ganglion*/metabolism
Trigeminal Ganglion*/pathology
Trigeminal Ganglion*/physiopathology
Freund's Adjuvant/*adverse effects
Amygdala/metabolism ; Amygdala/pathology ; Amygdala/physiopathology ; Animals ; Cytokines/metabolism ; Freund's Adjuvant/pharmacology ; Inflammation/chemically induced ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation/physiopathology ; Locomotion ; Male ; Rats ; Rats, Wistar
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Substance Nomenclature:
0 (Cytokines)
9007-81-2 (Freund's Adjuvant)
Entry Date(s):
Date Created: 20181113 Date Completed: 20190416 Latest Revision: 20190416
Update Code:
20240105
PubMed Central ID:
PMC6231674
DOI:
10.1371/journal.pone.0207411
PMID:
30419075
Czasopismo naukowe
This study further investigated the mechanisms underlying the rat model of tooth pulp inflammatory pain elicited by complete Freund's adjuvant (CFA), in comparison to other pulpitis models. Pulps of the left maxillary first molars were accessed. In the CFA group, the pulps were exposed, and CFA application was followed by dental sealing. In the open group, the pulps were left exposed to the oral cavity. For the closed group, the pulps were exposed, and the teeth were immediately sealed. Naïve rats were used as negative controls. Several parameters were evaluated at 1, 2, 3 and 8 days. There was no statistical significant difference among the groups when body weight variation, food or water consumption were compared. Analysis of serum cytokines (IL-1β, TNF or IL-6) or differential blood cell counts did not reveal any evidence of systemic inflammation. The CFA group displayed a significant reduction in the locomotor activity (at 1 and 3 days), associated with an increased activation of satellite glial cells in the ipsilateral trigeminal ganglion (TG; for up to 8 days). Amygdala astrocyte activation was unaffected in any experimental groups. We provide novel evidence indicating that CFA-induced pulp inflammation impaired the locomotor activity, with persistent activation of ipsilateral TG satellite cells surrounding sensory neurons, without any evidence of systemic inflammation or amygdala astrogliosis.
Competing Interests: The authors have declared that no competing interests exist.
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