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Tytuł:
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Physiological role of adiponectin in different tissues: a review.
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Autorzy:
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Esmaili S; Student Research Committee, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Hemmati M; Cardiovascular Disease Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Karamian M; Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
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Źródło:
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Archives of physiology and biochemistry [Arch Physiol Biochem] 2020 Feb; Vol. 126 (1), pp. 67-73. Date of Electronic Publication: 2018 Nov 18.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: London : Informa Healthcare
Original Publication: Lisse, Netherlands : Swets & Zeitlinger, c1995-
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MeSH Terms:
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Adiponectin/*genetics
Adipose Tissue/*physiology
Atherosclerosis/*genetics
Kidney/*physiology
Liver/*physiology
Obesity/*genetics
AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Adiponectin/metabolism ; Adipose Tissue/cytology ; Animals ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Gene Expression Regulation ; Humans ; Insulin Resistance ; Kidney/cytology ; Liver/cytology ; Obesity/metabolism ; Obesity/pathology ; Organ Specificity ; Oxidation-Reduction ; Oxidative Stress ; Receptors, Adiponectin/genetics ; Receptors, Adiponectin/metabolism ; Signal Transduction
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Contributed Indexing:
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Keywords: Adiponectin; adipose tissue; metabolic diseases; oxidative stress
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Substance Nomenclature:
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0 (ADIPOQ protein, human)
0 (ADIPOR1 protein, human)
0 (Adiponectin)
0 (Receptors, Adiponectin)
EC 2.7.11.31 (AMP-Activated Protein Kinases)
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Entry Date(s):
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Date Created: 20181120 Date Completed: 20200323 Latest Revision: 20200323
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Update Code:
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20240105
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DOI:
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10.1080/13813455.2018.1493606
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PMID:
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30451000
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Adiponectin is the most important adipokine secreted by the adipose tissue. It carries out an important role in setting up the metabolism and improving the function of various organs. Adiponectin in the kidneys prevents degradation of the renal arteries, reduces protein excretion, and improves filtration. This role is accomplished by regulating anabolic pathways and reducing oxidative stress in the renal tissue. This hormone in the liver prevents the accumulation of fat and free radicals that cause damage to liver cells and tissue. This adipokine, by preventing inflammatory processes, oxidative stress, obesity and insulin resistance, improves vascular function and prevents the development of atherosclerosis. It seems that adiponectin can also be a therapeutic target for many metabolic diseases. This study aims to clarify the adipose tissue discharge. Here, the diverse physiological actions of adiponectin were reviewed to provide an overview of its therapeutic potential in different metabolic disorders.
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