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Tytuł:
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Long agonal period deteriorates cardiac death donor lung function in a rat EVLP model.
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Autorzy:
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Hijiya K; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Chen-Yoshikawa TF; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. .
Motoyama H; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Ohsumi A; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Nakajima D; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Sakamoto J; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Aoyama A; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Date H; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
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Źródło:
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General thoracic and cardiovascular surgery [Gen Thorac Cardiovasc Surg] 2019 May; Vol. 67 (5), pp. 457-463. Date of Electronic Publication: 2018 Nov 23.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Tokyo : Springer Japan
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MeSH Terms:
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Death*
Lung Transplantation*
Lung/*physiopathology
Reperfusion Injury/*physiopathology
Tissue and Organ Procurement/*methods
Animals ; Blood Pressure ; Extracorporeal Circulation ; Male ; Perfusion ; Pulmonary Edema ; Rats ; Rats, Inbred Lew ; Reperfusion Injury/etiology ; Time Factors ; Tissue Donors ; Warm Ischemia/adverse effects
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References:
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Contributed Indexing:
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Keywords: Agonal period; Animal model; Controlled donation after cardiac death; Lung transplantation; Warm ischemic time
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Entry Date(s):
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Date Created: 20181125 Date Completed: 20190614 Latest Revision: 20200225
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Update Code:
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20240105
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DOI:
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10.1007/s11748-018-1038-3
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PMID:
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30471047
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Purpose: We investigated the impact of the duration of agonal period on donor lung function after reperfusion in an ex vivo rat lung perfusion model.
Methods: Three mechanical hypoventilation conditions were used for three agonal periods, which were defined as the interval between the start of hypoventilation and the time when systolic arterial blood pressure reached < 50 mmHg, i.e., < 10, 30-60, and 150-200 min for very short (VS), short (S), and long (L) groups (n = 5 rats/group). After flushing the lung, heart-lung blocks were reperfused ex vivo for 120 min; physiological data were obtained throughout the reperfusion process.
Results: Pulmonary vascular resistance was significantly higher throughout reperfusion in group L than in the other two groups (p < 0.05). After reperfusion, oxygenation was worse and pulmonary edema was more severe in group L than in group S (p < 0.05). Potassium concentrations in the perfusates were significantly higher in group L than in group VS. Histological analysis revealed more severe injury in group L than in the other two groups.
Conclusions: Long agonal periods may lead to deterioration of donor lung function; short intervals may not significantly affect donor lung function.