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Tytuł:
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Vitamin K 2 supplementation blocks the beneficial effects of IFN-α-2b administered on the early stages of liver cancer development in rats.
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Autorzy:
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Vera MC; Instituto de Fisiología Experimental (IFISE), Facultad de Ciencias Bioquímicas y Farmacéuticas, CONICET, UNR, Rosario, Argentina.
Lorenzetti F; Instituto de Fisiología Experimental (IFISE), Facultad de Ciencias Bioquímicas y Farmacéuticas, CONICET, UNR, Rosario, Argentina.
Lucci A; Instituto de Fisiología Experimental (IFISE), Facultad de Ciencias Bioquímicas y Farmacéuticas, CONICET, UNR, Rosario, Argentina; Área Morfología, Facultad de Ciencias Bioquímicas y Farmacéuticas, UNR, Rosario, Argentina.
Comanzo CG; Instituto de Fisiología Experimental (IFISE), Facultad de Ciencias Bioquímicas y Farmacéuticas, CONICET, UNR, Rosario, Argentina.
Ceballos MP; Instituto de Fisiología Experimental (IFISE), Facultad de Ciencias Bioquímicas y Farmacéuticas, CONICET, UNR, Rosario, Argentina.
Pisani GB; Área Morfología, Facultad de Ciencias Bioquímicas y Farmacéuticas, UNR, Rosario, Argentina.
Alvarez ML; Instituto de Fisiología Experimental (IFISE), Facultad de Ciencias Bioquímicas y Farmacéuticas, CONICET, UNR, Rosario, Argentina; Área Morfología, Facultad de Ciencias Bioquímicas y Farmacéuticas, UNR, Rosario, Argentina.
Quiroga AD; Instituto de Fisiología Experimental (IFISE), Facultad de Ciencias Bioquímicas y Farmacéuticas, CONICET, UNR, Rosario, Argentina; Área Morfología, Facultad de Ciencias Bioquímicas y Farmacéuticas, UNR, Rosario, Argentina.
Carrillo MC; Instituto de Fisiología Experimental (IFISE), Facultad de Ciencias Bioquímicas y Farmacéuticas, CONICET, UNR, Rosario, Argentina; Área Morfología, Facultad de Ciencias Bioquímicas y Farmacéuticas, UNR, Rosario, Argentina. Electronic address: .
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Źródło:
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Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2019 Mar; Vol. 59, pp. 170-179. Date of Electronic Publication: 2018 Aug 25.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Tarrytown, NY : Elsevier Science
Original Publication: [Burbank, Calif. : Nutrition, c1987-
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MeSH Terms:
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Dietary Supplements*
Antineoplastic Agents/*administration & dosage
Carcinogenesis/*drug effects
Interferon alpha-2/*administration & dosage
Vitamin K 2/*administration & dosage
Vitamins/*administration & dosage
Animals ; Apoptosis/drug effects ; Liver/drug effects ; Liver Neoplasms/drug therapy ; Male ; Precancerous Conditions/drug therapy ; Rats ; Rats, Wistar
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Contributed Indexing:
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Keywords: Apoptosis; Cytokine; Hepatocellular carcinoma; Proliferation; Vitamin supplementation
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Substance Nomenclature:
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0 (Antineoplastic Agents)
0 (Interferon alpha-2)
0 (Vitamins)
11032-49-8 (Vitamin K 2)
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Entry Date(s):
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Date Created: 20181130 Date Completed: 20200317 Latest Revision: 20200317
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Update Code:
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20240105
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DOI:
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10.1016/j.nut.2018.08.016
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PMID:
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30496957
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Objective: Vitamin K 2 , which is present in dairy products and has been recommended as a micronutrient supplement in humans, contains anticancer properties. Interferon (IFN)-α-2b administered during development of hepatic preneoplasia decreased both number and volume percentage of altered hepatic foci (AHF) by increasing apoptosis in the foci. The aim of this study was to evaluate the effects of IFN-α-2b treatment supplemented with vitamin K 2 in the early stages of liver cancer development in rats.
Methods: Adult male Wistar rats were subjected to a two-phase model of hepatocarcinogenesis (initiated-promoted [IP] group). Animals were divided into four groups: untreated (IP), IP treated with IFN-α-2b (6.5 × 10 5 U/kg), IP treated with vitamin K 2 (10 mg/kg), and IP treated with both compounds.
Results: The study results demonstrated that vitamin K 2 blocked IFN-α-2b-induced reduction in size and volume of the altered hepatic foci and inhibited IFN-α-2b-induced apoptosis. Its inhibition of IFN-α-2b-induced apoptosis was mediated by increased levels of total hepatic Bcl-2 in rat preneoplastic livers.
Conclusion: These findings demonstrate that supportive vitamin supplements or therapies are not always safe because they could put the life of patients treated with IFN-α-2b at risk.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
