-
Tytuł:
-
Trials with the Haemonchus vaccine, Barbervax , in ewes and lambs in a tropical environment: Nutrient supplementation improves protection in periparturient ewes.
-
Autorzy:
-
Bassetto CC; UNESP - Universidade Estadual Paulista, Departamento de Parasitologia, Instituto de Biociências, Botucatu, SP, CEP 18.618-689, Brazil. Electronic address: .
Almeida FA; UNESP - Universidade Estadual Paulista, Departamento de Parasitologia, Instituto de Biociências, Botucatu, SP, CEP 18.618-689, Brazil.
Newlands GFJ; Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh, UK.
Smith WD; Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh, UK.
Castilhos AM; UNESP - Universidade Estadual Paulista, Departamento de Produção Animal, Faculdade de Medicina Veterinária e Zootecnia, Fazenda Experimental Lageado, Botucatu, SP, Brazil.
Fernandes S; UNESP - Universidade Estadual Paulista, Departamento de Produção Animal, Faculdade de Medicina Veterinária e Zootecnia, Fazenda Experimental Lageado, Botucatu, SP, Brazil.
Siqueira ER; UNESP - Universidade Estadual Paulista, Departamento de Produção Animal, Faculdade de Medicina Veterinária e Zootecnia, Fazenda Experimental Lageado, Botucatu, SP, Brazil.
Amarante AFT; UNESP - Universidade Estadual Paulista, Departamento de Parasitologia, Instituto de Biociências, Botucatu, SP, CEP 18.618-689, Brazil.
-
Źródło:
-
Veterinary parasitology [Vet Parasitol] 2018 Dec 15; Vol. 264, pp. 52-57. Date of Electronic Publication: 2018 Nov 08.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Publication: Amsterdam : Elsevier
Original Publication: Amsterdam : Elsevier Scientific Pub. Co.
-
MeSH Terms:
-
Dietary Supplements*
Haemonchiasis/*veterinary
Nutrients/*immunology
Sheep Diseases/*immunology
Sheep Diseases/*prevention & control
Vaccines/*immunology
Animals ; Antibodies, Helminth/blood ; Female ; Haemonchiasis/immunology ; Haemonchiasis/prevention & control ; Haemonchus/immunology ; Nutrients/administration & dosage ; Pregnancy ; Sheep ; Tropical Climate ; Vaccines/administration & dosage ; Weight Gain/immunology
-
Contributed Indexing:
-
Keywords: Haemonchosis; Improved nutrition; Parasitic gastroenteritis; Prophylaxis; Sheep
-
Substance Nomenclature:
-
0 (Antibodies, Helminth)
0 (Vaccines)
-
Entry Date(s):
-
Date Created: 20181204 Date Completed: 20181218 Latest Revision: 20191210
-
Update Code:
-
20240105
-
DOI:
-
10.1016/j.vetpar.2018.11.006
-
PMID:
-
30503092
-
Haemonchus contortus is an economic problem in sheep farms worldwide, mainly in the tropics and subtropics. A vaccine against haemonchosis, called Barbervax ® , was evaluated in ewes under two nutritional status, naturally infected with gastrointestinal nematodes. Ewes were divided into four groups: Supplemented Diet - Vaccine; Supplemented Diet - No vaccine; Basal Diet - Vaccine and Basal Diet - No vaccine. Their lambs were divided in Vaccinated and No vaccine. Ewes were immunised six times starting about 1 month of pregnancy with the first three doses at 3 week intervals and the last three shots at 4 week intervals. Supplemented ewes had higher body weight, body score and packed cell volume compared with those fed a basal diet. Both groups of vaccinated ewes showed a similar response in circulating anti-vaccine antibodies but the vaccine had no discernible effect on either body weight, body score and packed cell volume. There was a marked group difference in the number of ewes that received precautionary treatments with anthelmintic. All 14 Basal Diet - No vaccine ewes required treatment. In contrast only 7 ewes, in the Supplemented Diet - Vaccine group required anthelmintic treatment. In the Basal Diet - Vaccine and in the Supplemented Diet - No Vaccine groups, 12 and 13 ewes needed anthelmintic treatment, respectively. Vaccinated lambs showed much higher antibody titres resulting in 80% less Haemonchus spp. egg counts comparing with no vaccine lambs. Taken together these results clearly suggest that in pregnant and lactating ewes a combined protective effect between vaccination and improved nutrition resulted in fewer precautionary anthelmintic treatments. Thus, it was possible to achieve a more sustainable level of control of the haemonchosis, less dependent on anthelmintic drugs.
(Copyright © 2018 Elsevier B.V. All rights reserved.)