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Tytuł:
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A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-κB mediated apoptosis-to-pyroptosis switch.
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Autorzy:
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Chen L; Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Weng B; Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.; Department of Pharmaceutical Sciences, Tonglu First Peoples Hospital, Hangzhou, 311500, Zhejiang, China.
Li H; Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.; Department of Periodontics, Hospital & School of Stomatology, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Wang H; Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Li Q; Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Wei X; Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.; Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.
Deng H; Department of Periodontics, Hospital & School of Stomatology, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Wang S; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710049, Shanxi, China.
Jiang C; Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Lin R; Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. .; Department of Otorhinolaryngology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. .
Wu J; Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. .
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Źródło:
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Apoptosis : an international journal on programmed cell death [Apoptosis] 2019 Feb; Vol. 24 (1-2), pp. 74-82.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: 2005- : Dordrecht, Netherlands : Springer
Original Publication: London : Rapid Science Publishers,
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MeSH Terms:
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Apoptosis/*drug effects
Lung Neoplasms/*drug therapy
Pyrans/*therapeutic use
Pyroptosis/*drug effects
Sulfhydryl Compounds/*chemistry
A549 Cells ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/physiology ; Cell Line, Tumor ; Female ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mice ; Mice, Inbred BALB C ; NF-kappa B/metabolism ; Pyrans/chemistry ; Pyrans/pharmacology ; Pyroptosis/physiology ; RAW 264.7 Cells ; Signal Transduction/drug effects ; Sulfhydryl Compounds/pharmacology ; Sulfhydryl Compounds/therapeutic use ; Toxicity Tests ; Xenograft Model Antitumor Assays
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References:
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Grant Information:
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2015KYA1506 International The Technology Foundation for Medical Science of Zhejiang Province; Grant Nos. LY17H160059 International The Zhejiang Province Natural Science Fund of China; LY15H280014 International The Zhejiang Province Natural Science Fund of China; LY19H130001 International The Zhejiang Province Natural Science Fund of China; Grant Nos. 81272462 International The National Natural Science Foundation of China
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Contributed Indexing:
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Keywords: Anti-lung cancer; Apoptosis; NF-κB; Pyroptosis; Toxicity
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Substance Nomenclature:
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0 (Antineoplastic Agents)
0 (NF-kappa B)
0 (Pyrans)
0 (Sulfhydryl Compounds)
0 (thiopyran)
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Entry Date(s):
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Date Created: 20181207 Date Completed: 20200420 Latest Revision: 20211115
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Update Code:
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20240105
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DOI:
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10.1007/s10495-018-1499-y
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PMID:
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30519834
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Pyroptosis is a novel manner of cell death that can be mediated by chemotherapy drugs. The awareness of pyroptosis is significantly increasing in the fields of anti-tumor research and chemotherapy drugs. Invoking the occurrence of pyroptosis is an attractive prospect for the treatment of lung cancer. Here, the compound L61H10 was obtained as a thiopyran derivative to compare its activity with curcumin. It was indicated that L61H10 exhibited good anti-tumor activity both in vitro and in vivo via the switch of apoptosis-to-pyroptosis, which was associated with the NF-κB signaling pathway. In addition, L61H10 had no obvious side effects both in vitro and in vivo. In brief, L61H10 is shown to be a potential anti-lung cancer agent and research on its anti-tumor mechanism provides new information for chemotherapy drug research.