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Tytuł:
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Hepatitis E virus is not detected in association with neurological disorders among Brazilian children.
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Autorzy:
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Morgado LN; Instituto Oswaldo Cruz, Fiocruz, Laboratório de Enterovírus and Laboratório de Desenvolvimento Tecnológico em Virologia, Rio de Janeiro, RJ, Brazil.
de Oliveira JM; Instituto Oswaldo Cruz, Fiocruz, Laboratório de Enterovírus and Laboratório de Desenvolvimento Tecnológico em Virologia, Rio de Janeiro, RJ, Brazil.
Pinto MA; Instituto Oswaldo Cruz, Fiocruz, Laboratório de Enterovírus and Laboratório de Desenvolvimento Tecnológico em Virologia, Rio de Janeiro, RJ, Brazil.
Burlandy FM; Instituto Oswaldo Cruz, Fiocruz, Laboratório de Enterovírus and Laboratório de Desenvolvimento Tecnológico em Virologia, Rio de Janeiro, RJ, Brazil.
E da Silva E; Instituto Oswaldo Cruz, Fiocruz, Laboratório de Enterovírus and Laboratório de Desenvolvimento Tecnológico em Virologia, Rio de Janeiro, RJ, Brazil. Electronic address: .
da Silva JP; Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Niterói, RJ, Brazil.
Vitral CL; Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Niterói, RJ, Brazil. Electronic address: .
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Źródło:
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Microbes and infection [Microbes Infect] 2019 Apr - May; Vol. 21 (3-4), pp. 133-135. Date of Electronic Publication: 2018 Dec 07.
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Typ publikacji:
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Letter; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: Paris ; New York : Elsevier, c1999-
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MeSH Terms:
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Hepatitis E virus/*isolation & purification
Nervous System Diseases/*virology
Brazil/epidemiology ; Child ; Feces/virology ; Guillain-Barre Syndrome/epidemiology ; Guillain-Barre Syndrome/virology ; Hepatitis E virus/genetics ; Humans ; Muscle Hypotonia/diagnosis ; Muscle Hypotonia/epidemiology ; Muscle Hypotonia/virology ; Negative Results ; Nervous System Diseases/epidemiology ; Nervous System Diseases/etiology ; Paralysis/epidemiology ; Paralysis/etiology ; Paralysis/virology
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Contributed Indexing:
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Keywords: Acute flaccid paralysis; Brazil; Guillain-barré syndrome; Hepatitis E
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Entry Date(s):
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Date Created: 20181212 Date Completed: 20200203 Latest Revision: 20200203
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Update Code:
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20240105
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DOI:
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10.1016/j.micinf.2018.11.003
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PMID:
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30529325
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Hepatitis E virus is increasingly being associated with idiopathic neurological disease. We tested 325 stool samples from Brazilian children presenting acute flaccid paralysis or Guillain-Barré syndrome using a broadly reactive and sensitive Reverse-transcription Polymerase chain reaction. Hepatitis E genome was not detected in any of the samples tested. Our results suggest that hepatitis E virus does not seem to be associated as the etiologic agent of acute flaccid paralysis and Guillain-Barré syndrome cases occurred in Brazilian children during the period of investigation (2010-2012).
(Copyright © 2018. Published by Elsevier Masson SAS.)
