Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia.

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Abstrakt

Tytuł:: Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia.
Autorzy:: Rubin LH; Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States of America; Departments of Neurology and Epidemiology, Johns Hopkins University, Baltimore, MD, United States of America.
Li S; Department of Radiology, West China Hospital of Sichuan University, Chengdu, People's Republic of China.
Yao L; Department of Radiology, West China Hospital of Sichuan University, Chengdu, People's Republic of China.
Keedy SK; Department of Psychiatry, University of Chicago, Chicago, IL, United States of America.
Reilly JL; Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, United States of America.
Hill SK; Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, IL, United States of America.
Bishop JR; Departments of Pharmacy and Psychiatry, University of Minnesota, Minneapolis, MN, United States of America.
Sue Carter C; Kinsey Institute, Bloomington, IN, United States of America.
Pournajafi-Nazarloo H; Kinsey Institute, Bloomington, IN, United States of America.
Drogos LL; Departments of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Gershon E; Department of Psychiatry, University of Chicago, Chicago, IL, United States of America.
Pearlson GD; Departments of Psychiatry and Neurobiology, Yale University and Olin Neuropsychiatric Research Center, Hartford, CT, United States of America.
Tamminga CA; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States of America.
Clementz BA; Department of Psychology, University of Georgia, Athens, GA, United States of America.
Keshavan MS; Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States of America.
Lui S; Department of Radiology, West China Hospital of Sichuan University, Chengdu, People's Republic of China. Electronic address: .
Sweeney JA; Department of Radiology, West China Hospital of Sichuan University, Chengdu, People's Republic of China; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States of America; Department of Psychiatry, University of Cincinnati, United States of America.
Źródło:: Schizophrenia research [Schizophr Res] 2018 Dec; Vol. 202, pp. 173-179. Date of Electronic Publication: 2018 Jul 06.
Typ publikacji:: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Amsterdam : Elsevier Science Publisher B. V., c1988-
MeSH Terms:: Sex Characteristics*
Brain/*physiopathology
Neurophysins/*blood
Oxytocin/*blood
Protein Precursors/*blood
Schizophrenia/*physiopathology
Vasopressins/*blood
Adult ; Brain/diagnostic imaging ; Brain Mapping ; Cross-Sectional Studies ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Rest ; Schizophrenia/diagnostic imaging
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Grant Information:: K23 MH083126 United States MH NIMH NIH HHS; K08 MH083888 United States MH NIMH NIH HHS; R01 MH077862 United States MH NIMH NIH HHS; K12 HD055892 United States HD NICHD NIH HHS; R01 MH077851 United States MH NIMH NIH HHS; R01 MH103366 United States MH NIMH NIH HHS; R01 MH078113 United States MH NIMH NIH HHS; R01 MH077945 United States MH NIMH NIH HHS; R01 MH077852 United States MH NIMH NIH HHS
Contributed Indexing:: Keywords: Functional MRI; Oxytocin; Resting state; Schizophrenia; Sex differences; Vasopressin
Substance Nomenclature:: 0 (AVP protein, human)
0 (Neurophysins)
0 (Protein Precursors)
11000-17-2 (Vasopressins)
50-56-6 (Oxytocin)
Entry Date(s):: Date Created: 20181213 Date Completed: 20191028 Latest Revision: 20191201
Update Code:: 20240105
PubMed Central ID:: PMC6293995
DOI:: 10.1016/j.schres.2018.07.003
PMID:: 30539769
: Czasopismo naukowe

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Background: Oxytocin (OT) and arginine vasopressin (AVP) exert sexually dimorphic effects on cognition and emotion processing. Abnormalities in these hormones are observed in schizophrenia and may contribute to multiple established sex differences associated with the disorder. Here we examined sex-dependent hormone associations with resting brain activity and their clinical associations in schizophrenia patients.
Methods: OT and AVP serum concentrations were assayed in 35 individuals with schizophrenia (23 men) and 60 controls (24 men) from the Chicago BSNIP study site. Regional cerebral function was assessed with resting state fMRI by measuring the amplitude of low-frequency fluctuations (ALFF) which are believed to reflect intrinsic spontaneous neuronal activity.
Results: In female patients, lower OT levels were associated with lower ALFF in frontal and cerebellar cortices (p's < 0.05) and in female controls AVP levels were inversely associated with ALFF in the frontal cortex (p = 0.01). In male patients, lower OT levels were associated with lower ALFF in the posterior cingulate and lower AVP levels were associated with lower ALFF in frontal cortex (p's < 0.05). In male controls, lower OT levels were associated with lower ALFF in frontal cortex and higher ALFF in the thalamus (p's < 0.05). There were some inverse ALFF-behavior associations in patients.
Conclusions: Alterations in peripheral hormone levels are associated with resting brain physiology in a sex-dependent manner in schizophrenia. These effects may contribute to sex differences in psychiatric symptom severity and course of illness in schizophrenia.
(Copyright © 2018 Elsevier B.V. All rights reserved.)

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