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Tytuł pozycji:

Gold nanorods-conjugated TiO 2 nanoclusters for the synergistic combination of phototherapeutic treatments of cancer cells.

Tytuł :
Gold nanorods-conjugated TiO 2 nanoclusters for the synergistic combination of phototherapeutic treatments of cancer cells.
Autorzy :
Lee J; Division of Scientific Instrumentation, Korea Basic Science Institute, Daejeon, 34133, Republic of Korea.; Medical Device Development Center, Osong Medical Innovation Foundation, Cheongju, Chungbuk, 28160, Republic of Korea.
Lee YH; Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, 34134, Republic of Korea.
Jeong CB; Division of Scientific Instrumentation, Korea Basic Science Institute, Daejeon, 34133, Republic of Korea.
Choi JS; Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, 34134, Republic of Korea.
Chang KS; Division of Scientific Instrumentation, Korea Basic Science Institute, Daejeon, 34133, Republic of Korea. .
Yoon M; Department of Chemistry, College of Natural Sciences, Chungnam National University, Daejeon, 34134, Republic of Korea. .
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Źródło :
Journal of nanobiotechnology [J Nanobiotechnology] 2018 Dec 20; Vol. 16 (1), pp. 104. Date of Electronic Publication: 2018 Dec 20.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: London : BioMed Central, 2003-
MeSH Terms :
Gold*
Metal Nanoparticles*
Photochemotherapy*/methods
Titanium*
Nanotubes/*chemistry
Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; HeLa Cells ; Humans ; Photosensitizing Agents/chemistry
References :
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Grant Information :
D38615 Korea Basic Science Institute
Contributed Indexing :
Keywords: Cancer therapy; Gold nanorods; HeLa cells; Photodynamic therapy; Phototherapeutic nanocomplexes; Photothermal therapy; TiO2 nanoclusters
Substance Nomenclature :
0 (Antineoplastic Agents)
0 (Photosensitizing Agents)
15FIX9V2JP (titanium dioxide)
7440-57-5 (Gold)
D1JT611TNE (Titanium)
Entry Date(s) :
Date Created: 20181222 Date Completed: 20190730 Latest Revision: 20200225
Update Code :
20210914
PubMed Central ID :
PMC6300922
DOI :
10.1186/s12951-018-0432-4
PMID :
30572896
Czasopismo naukowe
Background: Recently, a combination of photodynamic therapy (PDT) and photothermal therapy (PTT) to generate reactive oxygen species (ROS) and heat to kill cancer cells, respectively has attracted considerable attention because it gives synergistic effects on the cancer treatment by utilizing the radiation of nontoxic low-energy photons such as long wavelength visible light and near IR (NIR) penetrating into subcutaneous region. For the effective combination of the phototherapies, various organic photosensitizer-conjugated gold nanocomplexes have been developed, but they have still some disadvantages due to photobleaching and unnecessary energy transfer of the organic photosensitizers.
Results: In this study, we fabricated novel inorganic phototherapeutic nanocomplexes (Au NR-TiO 2 NCs) by conjugating gold nanorods (Au NRs) with defective TiO 2 nanoparticle clusters (d-TiO 2 NP clusters) and characterized their optical and photothermal properties. They were observed to absorb a broad range of visible light and near IR (NIR) from 500 to 1000 nm, exhibiting the generation of ROS as well as the photothermal effect for the simultaneous application of PDT and PTT. The resultant combination of PDT and PTT treatments of HeLa cells incubated with the nanocomplexes caused a synergistic increase in the cell death compared to the single treatment.
Conclusion: The higher efficacy of cell death by the combination of PDT and PTT treatments with the nanocomplexes is likely attributed to the increases of ROS generation from the TiO 2 NCs with the aid of local surface plasma resonance (LSPR)-induced hot electrons and heat generation from Au NRs, suggesting that Au NR-TiO 2 NCs are promising nanomaterials for the in vivo combinatorial phototherapy of cancer.
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