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Tytuł pozycji:

Serum periostin levels in adults of Chinese descent: an observational study.

Tytuł:
Serum periostin levels in adults of Chinese descent: an observational study.
Autorzy:
Tan E; 1Medical Research Institute of New Zealand, Private Bag 7902, Newtown, Wellington, 6242 New Zealand.
Varughese R; 1Medical Research Institute of New Zealand, Private Bag 7902, Newtown, Wellington, 6242 New Zealand.
Semprini R; 1Medical Research Institute of New Zealand, Private Bag 7902, Newtown, Wellington, 6242 New Zealand.; 2Victoria University of Wellington, Wellington, New Zealand.
Montgomery B; Optimal Clinical Trials, Auckland, New Zealand.
Holweg C; 3Genentech Inc, San Francisco, California USA.
Olsson J; 3Genentech Inc, San Francisco, California USA.
Caswell-Smith R; 1Medical Research Institute of New Zealand, Private Bag 7902, Newtown, Wellington, 6242 New Zealand.
Fingleton J; 1Medical Research Institute of New Zealand, Private Bag 7902, Newtown, Wellington, 6242 New Zealand.; 5Capital & Coast District Health Board, Wellington, New Zealand.
Weatherall M; 1Medical Research Institute of New Zealand, Private Bag 7902, Newtown, Wellington, 6242 New Zealand.; 4University of Otago, Wellington, New Zealand.
Beasley R; 1Medical Research Institute of New Zealand, Private Bag 7902, Newtown, Wellington, 6242 New Zealand.; 2Victoria University of Wellington, Wellington, New Zealand.; 5Capital & Coast District Health Board, Wellington, New Zealand.
Braithwaite I; 1Medical Research Institute of New Zealand, Private Bag 7902, Newtown, Wellington, 6242 New Zealand.; 2Victoria University of Wellington, Wellington, New Zealand.; 5Capital & Coast District Health Board, Wellington, New Zealand.
Źródło:
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology [Allergy Asthma Clin Immunol] 2018 Dec 18; Vol. 14, pp. 87. Date of Electronic Publication: 2018 Dec 18 (Print Publication: 2018).
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: Oct. 2009- : London : BioMed Central
Original Publication: Hamilton, Ont. : BC Decker, c2004-
References:
Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1241-6. (PMID: 10764318)
Clin Exp Allergy. 2002 Jul;32(7):1033-41. (PMID: 12100050)
Thorax. 1992 Feb;47(2):76-83. (PMID: 1549827)
J Allergy Clin Immunol. 2005 Apr;115(4):751-7. (PMID: 15805994)
Am J Respir Crit Care Med. 2005 Apr 15;171(8):912-30. (PMID: 15817806)
Clin Exp Allergy. 2005 Jul;35(7):889-93. (PMID: 16008675)
Eur Respir J. 2005 Aug;26(2):319-38. (PMID: 16055882)
Respir Med. 2006 Apr;100(4):616-21. (PMID: 16226443)
J Allergy Clin Immunol. 2006 Jul;118(1):98-104. (PMID: 16815144)
Respir Res. 2009 Apr 21;10:28. (PMID: 19379527)
J Allergy Clin Immunol. 2009 Sep;124(3):447-53. (PMID: 19647861)
Chest. 2011 Nov;140(5):1325-1331. (PMID: 21527509)
N Engl J Med. 2011 Sep 22;365(12):1088-98. (PMID: 21812663)
Eur Respir J. 2012 Dec;40(6):1324-43. (PMID: 22743675)
J Allergy Clin Immunol. 2012 Sep;130(3):647-654.e10. (PMID: 22857879)
Am J Respir Crit Care Med. 2013 Apr 15;187(8):804-11. (PMID: 23471469)
J Allergy Clin Immunol. 2013 Aug;132(2):305-12.e3. (PMID: 23791506)
J Allergy Clin Immunol. 2013 Oct;132(4):821-7.e1-5. (PMID: 23890753)
Respir Med. 2013 Nov;107(11):1682-91. (PMID: 24041745)
Allergol Int. 2014 Jun;63(2):153-60. (PMID: 24759559)
Thorax. 2015 Feb;70(2):105-7. (PMID: 25432945)
Lancet Respir Med. 2015 Sep;3(9):692-701. (PMID: 26231288)
Eur Respir J. 2016 May;47(5):1383-91. (PMID: 26917610)
J Allergy Clin Immunol. 2016 Jun;137(6):1904-1907.e2. (PMID: 27061252)
Clin Exp Allergy. 2016 Oct;46(10):1303-14. (PMID: 27237923)
Clin Biochem. 2017 Feb;50(3):139-144. (PMID: 27725167)
J Clin Pathol. 1984 Feb;37(2):188-93. (PMID: 6693578)
Contributed Indexing:
Keywords: Adult; Asthma; Biomarkers; Chinese; Periostin
Entry Date(s):
Date Created: 20181222 Latest Revision: 20220330
Update Code:
20240105
PubMed Central ID:
PMC6299536
DOI:
10.1186/s13223-018-0312-3
PMID:
30574168
Czasopismo naukowe
Background: Periostin has been shown to be a marker of Type 2 airway inflammation, associated with airway eosinophilia. It has a potential role in identifying asthmatics who may be responsive to treatment with monoclonal antibody therapy directed against Type 2 cytokines, such as interleukin (IL)-13, IL-4 receptor subunit-α and immunoglobulin E. The clinical utility of periostin measurements depends on better understanding of factors that may affect serum periostin levels, such as race. We aimed to identify the ranges of serum periostin in Chinese adults both with and without asthma, and compare them with those previously identified in Caucasian adults.
Methods: A two-centred cross-sectional study, recruiting 188 Chinese adults, aged 18 to 75 years. 120 participants had no history of asthma or chronic obstructive pulmonary disease. 68 participants had a doctor's diagnosis of asthma and were on current treatment. Univariate comparisons of periostin by dichotomous variables were made using t-tests with logarithmic transformation as the distribution of periostin was skewed.
Results: In the Chinese non-asthma group, periostin levels were sex-, but not age-dependent, with females having higher periostin levels. The individual predicted (90% CI) reference range for periostin in females was 61.1 ng/ml (41.6 to 89.8) ng/ml and in males was 53.2 ng/ml (36.1 to 78.3) ng/ml. There was no difference in median serum periostin levels between Chinese non-asthmatics and Chinese asthmatics, 57.0 versus 56.8 ng/ml, difference (95% CI) 0.1 (- 4.2 to 4.2) ng/ml, P = 0.94. The median serum periostin levels were higher in Chinese non-asthmatics than Caucasian non-asthmatics, 57.0 versus 49.7 ng/ml, difference (95% CI) 8.2 (5.8-10.6) ng/ml, P < 0.001.
Conclusions: Serum periostin does not discriminate between asthmatics and non-asthmatics and is therefore not a good biomarker to diagnose asthma. Serum periostin levels were higher in the Chinese compared to the Caucasian non-asthma group, and also sex dependent in the Chinese participants. There was no difference in serum periostin levels between Chinese non-asthma and asthma groups. This suggests that ethnicity should be considered in the interpretation of periostin levels in asthma patients and sex is an additional consideration in Chinese patients. Trial registration This trial was prospectively registered with Australian New Zealand Clinical Trials Registry (ACTRN12614000122651).
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