Decomposing the constituent oscillatory dynamics underlying mismatch negativity generation in schizophrenia: Distinct relationships to clinical and cognitive functioning.

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Tytuł:: Decomposing the constituent oscillatory dynamics underlying mismatch negativity generation in schizophrenia: Distinct relationships to clinical and cognitive functioning.
Autorzy:: Hochberger WC; VISN-22 Mental Illness, Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, United States of America; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States of America.
Joshi YB; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States of America.
Zhang W; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States of America.
Thomas ML; Colorado State University, Department of Psychology, Fort Collins, CO, United States of America.
Braff DL; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States of America.
Swerdlow NR; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States of America.
Light GA; VISN-22 Mental Illness, Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, United States of America; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States of America. Electronic address: .
Corporate Authors:: Consortium of Genomics in Schizophrenia (COGS) investigators
Źródło:: International journal of psychophysiology : official journal of the International Organization of Psychophysiology [Int J Psychophysiol] 2019 Nov; Vol. 145, pp. 23-29. Date of Electronic Publication: 2018 Dec 23.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Język:: English
Imprint Name(s):: Original Publication: Amsterdam ; New York : Elsevier, [c1983-
MeSH Terms:: Brain/*physiopathology
Cognition/*physiology
Evoked Potentials/*physiology
Schizophrenia/*physiopathology
Acoustic Stimulation ; Adult ; Electroencephalography ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Reaction Time/physiology
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Grant Information:: R37 MH042228 United States MH NIMH NIH HHS; R25 MH101072 United States MH NIMH NIH HHS; R01 MH042228 United States MH NIMH NIH HHS; R01 MH065571 United States MH NIMH NIH HHS; R01 MH065558 United States MH NIMH NIH HHS; R01 MH094320 United States MH NIMH NIH HHS; R01 MH065707 United States MH NIMH NIH HHS; K01 MH087889 United States MH NIMH NIH HHS; R01 MH079777 United States MH NIMH NIH HHS; R01 MH065554 United States MH NIMH NIH HHS; R01 MH065578 United States MH NIMH NIH HHS
Contributed Indexing:: Keywords: COGS-2; Early auditory information processing; Mismatch negativity; Schizophrenia
Entry Date(s):: Date Created: 20181227 Date Completed: 20200525 Latest Revision: 20240328
Update Code:: 20240329
PubMed Central ID:: PMC7261144
DOI:: 10.1016/j.ijpsycho.2018.12.014
PMID:: 30586570
: Czasopismo naukowe

Abnormalities in early auditory information processing (EAIP) contribute to higher-order deficits in cognition and psychosocial functioning in schizophrenia. A passive auditory oddball paradigm is commonly used to evoke event-related potential (ERP) measures of EAIP reflecting auditory sensory registration and deviance detection, including mismatch negativity (MMN) and P3a responses. MMN and P3a have been extensively studied in healthy subjects and neuropsychiatric patient populations and are increasingly used as translational biomarkers in the development of novel therapeutics. Despite widespread use, relatively few studies have examined the constituent oscillatory elements and the extent to which sensory registration and deviance detection represent distinct or intercorrelated processes. This study aimed to determine the factor structure and clinical correlates of these oscillatory measures in schizophrenia patients (n = 706) and healthy comparison subjects (n = 615) who underwent clinical, cognitive, and functional characterization and EEG testing via their participation in the Consortium of Genomics in Schizophrenia (COGS-2) study. Results revealed significant deficits in theta-band (4-7 Hz) evoked power and phase locking in patients. Exploratory factor analyses of both ERP and oscillatory measures revealed two dissociable factors reflecting sensory registration and deviance detection. While each factor shared a significant correlation with social cognition, the deviance detection factor had a unique relationship to multiple cognitive and clinical domains. Results support the continued advancement of functionally relevant oscillatory measures underlying EAIP in the development of precognitive therapeutics.
(Published by Elsevier B.V.)

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