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Tytuł pozycji:

Possible Metabolic Alterations among Autistic Male Children: Clinical and Biochemical Approaches.

Tytuł :
Possible Metabolic Alterations among Autistic Male Children: Clinical and Biochemical Approaches.
Autorzy :
Hassan MH; Department of Medical Biochemistry, Faculty of Medicine, South Valley University, Qena, Egypt. .
Desoky T; Department of Neuropsychiatry, Faculty of Medicine, South Valley University, Qena, Egypt.
Sakhr HM; Department of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt.
Gabra RH; Department of Neuropsychiatry, Faculty of Medicine, Assiut University, Assiut, Egypt.
Bakri AH; Department of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt.
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Źródło :
Journal of molecular neuroscience : MN [J Mol Neurosci] 2019 Feb; Vol. 67 (2), pp. 204-216. Date of Electronic Publication: 2019 Jan 02.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: Totowa, NJ : Humana Press
Original Publication: Boston : Birkhäuser [i.e. Cambridge, MA : Birkhäuser Boston, c1989-
MeSH Terms :
Metabolome*
Autistic Disorder/*blood
Adenosine Deaminase/blood ; Antigens, Bacterial/analysis ; Autistic Disorder/physiopathology ; Biomarkers/blood ; Child ; Child, Preschool ; Cholesterol/blood ; Gonadal Steroid Hormones/blood ; Helicobacter pylori/immunology ; Humans ; Hydrocortisone/blood ; Male ; Metals, Heavy/blood ; Mitochondria/metabolism ; Oxidative Stress
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Contributed Indexing :
Keywords: Abnormal metabolism; Autism; Biochemical assessments; CARS; IQ; SSP
Substance Nomenclature :
0 (Antigens, Bacterial)
0 (Biomarkers)
0 (Gonadal Steroid Hormones)
0 (Metals, Heavy)
97C5T2UQ7J (Cholesterol)
EC 3.5.4.4 (Adenosine Deaminase)
WI4X0X7BPJ (Hydrocortisone)
Entry Date(s) :
Date Created: 20190103 Date Completed: 20190219 Latest Revision: 20200225
Update Code :
20210210
DOI :
10.1007/s12031-018-1225-9
PMID :
30600432
Czasopismo naukowe
The present cross-sectional, hospital-based study was carried out on 146 Egyptian male children, 73 males with autism who were comparable with another 73 healthy age- and sex-matched children, recruited from the outpatients' psychiatric clinics of the Neuropsychiatric and Pediatric Departments of South Valley and Assiut University Hospitals, Egypt. Neuropsychological assessments of autistic males were done using CARS, short sensory profile and intelligent quotients. Serum markers of mitochondrial dysfunction (lactate, pyruvate, and lactate to pyruvate ratio, creatine kinase (CK), L-carnitine, ammonia, lactate dehydrogenase, pyruvate kinase, alanine transaminase and aspartate transaminase), oxidative stress and blood levels of heavy metals (mercury, lead and aluminium) were measured. Serum cholesterol, cortisol, free testosterone, estradiol, dehydroepiandrostenedione, adenosine deaminase and Helicobacter pylori antigen in stool were also performed. There was evidence of mitochondrial dysfunction among autistic children. Additionally, there were significantly lower serum total cholesterol, cortisol and estradiol as well as significantly higher dehydroepiandrostenedione (DHEA) and free testosterone (p < 0.05 for all markers). Twenty-eight (38%) cases were positive for H. pylori antigen in their stool with significant higher serum ammonia and lower adenosine deaminase than in H. pylori-negative autistic children. Mitochondrial dysfunction, H. pylori infection and low cholesterol were prevalent among autistic male children, which should be targeted during autism management.

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