Lobular Breast Carcinoma Metastasis to the Thyroid Gland: Case Report and Literature Review.

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Tytuł:: Lobular Breast Carcinoma Metastasis to the Thyroid Gland: Case Report and Literature Review.
Autorzy:: Bourcier K; Department of Medical Oncology, Limoges University Hospital, Limoges, France.
Fermeaux V; Department of Pathology, Limoges University Hospital, Limoges, France.
Leobon S; Department of Medical Oncology, Limoges University Hospital, Limoges, France.
Deluche E; Department of Medical Oncology, Limoges University Hospital, Limoges, France.
Źródło:: Journal of breast cancer [J Breast Cancer] 2018 Dec; Vol. 21 (4), pp. 463-467. Date of Electronic Publication: 2018 Nov 27.
Typ publikacji:: Case Reports
Język:: English
Imprint Name(s):: Original Publication: Seoul : Korean Breast Cancer Society
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Contributed Indexing:: Keywords: Breast neoplasms; Immunohistochemistry; Lobular carcinoma; Neoplasm metastasis; Thyroid gland
Entry Date(s):: Date Created: 20190105 Latest Revision: 20201001
Update Code:: 20240105
PubMed Central ID:: PMC6310724
DOI:: 10.4048/jbc.2018.21.e55
PMID:: 30607169
: Raport

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Metastasis from primary cancer to the thyroid is uncommon in breast cancer. Here we present a case of lobular breast carcinoma that metastasized to the thyroid. A 54-year-old woman without symptoms was admitted to our institution for staging of the lymph node above the left clavicle. An 18 F-fluoro-deoxy-D-glucose positron emission tomography scan was performed for staging, and low uptakes were observed in the left supraclavicular and cervical lymph nodes. High uptake was seen in the posterior and lower left lobe of the thyroid. Histologic findings indicated lobular breast carcinoma (positive GATA3, loss of E-cadherin expression) metastatic to the thyroid with a luminal profile. Immunohistochemical analysis was negative for primary thyroid or parathyroid carcinoma. To our knowledge, this is the first report of a patient presenting a metastatic invasive lobular carcinoma in the thyroid and lymph nodes without a prior diagnosis of breast cancer.
Competing Interests: CONFLICT OF INTEREST: The authors declare that they have no competing interests.

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