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Tytuł:
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Lidocaine protects neurons of the spinal cord in an excitotoxicity model.
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Autorzy:
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Sisti MS; Image Analysis Laboratory, School of Veterinary Sciences, National University of La Plata (UNLP), 60 y 118, s/n, La Plata, Buenos Aires, Argentina; National Research Council of Science and Technology (CONICET), Argentina. Electronic address: .
Nishida F; Image Analysis Laboratory, School of Veterinary Sciences, National University of La Plata (UNLP), 60 y 118, s/n, La Plata, Buenos Aires, Argentina; National Research Council of Science and Technology (CONICET), Argentina. Electronic address: .
Zanuzzi CN; Image Analysis Laboratory, School of Veterinary Sciences, National University of La Plata (UNLP), 60 y 118, s/n, La Plata, Buenos Aires, Argentina; National Research Council of Science and Technology (CONICET), Argentina; Department of Histology and Embryology, School of Veterinary Sciences, National University of La Plata, 60 y 118, s/n, La Plata, Buenos Aires, Argentina. Electronic address: .
Laurella SL; CEDECOR, Department of Chemistry, School of Exact Sciences, Universidad Nacional de La Plata, 47 y 115, s/n, La Plata, Buenos Aires, Argentina. Electronic address: .
Cantet RJC; National Research Council of Science and Technology (CONICET), Argentina; Department of Animal Science, College of Agriculture, University of Buenos Aires, INPA CONICET, Av. San Martín 4453, Buenos Aires, Argentina. Electronic address: .
Portiansky EL; Image Analysis Laboratory, School of Veterinary Sciences, National University of La Plata (UNLP), 60 y 118, s/n, La Plata, Buenos Aires, Argentina; National Research Council of Science and Technology (CONICET), Argentina. Electronic address: .
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Źródło:
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Neuroscience letters [Neurosci Lett] 2019 Apr 17; Vol. 698, pp. 105-112. Date of Electronic Publication: 2019 Jan 09.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Limerick : Elsevier Scientific Publishers Ireland
Original Publication: Amsterdam, Elsevier/North-Holland.
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MeSH Terms:
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Lidocaine/*pharmacology
Neurons/*drug effects
Spinal Cord/*drug effects
Spinal Cord Injuries/*drug therapy
Animals ; Disease Models, Animal ; Excitatory Amino Acid Agonists/pharmacology ; Glutamic Acid/pharmacology ; Kainic Acid/pharmacology ; Male ; Neuroprotective Agents/pharmacology ; Rats, Sprague-Dawley ; Spinal Cord Injuries/pathology
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Contributed Indexing:
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Keywords: Excitotoxicity; Kainic acid; Lidocaine; Neuroprotection; Spinal cord injury
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Substance Nomenclature:
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0 (Excitatory Amino Acid Agonists)
0 (Neuroprotective Agents)
3KX376GY7L (Glutamic Acid)
98PI200987 (Lidocaine)
SIV03811UC (Kainic Acid)
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Entry Date(s):
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Date Created: 20190115 Date Completed: 20190910 Latest Revision: 20220409
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Update Code:
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20240104
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DOI:
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10.1016/j.neulet.2019.01.019
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PMID:
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30639396
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Motor Neuron Disease disorders, described in domestic animals, are characterized by neuronal degeneration at the spinal cord. Excitotoxicity is a crucial factor for the selective loss of these neurons, being the fundamental processes involved in lesion progression after spinal cord injury, where glutamate is one of the main neurotransmitters involved. Kainic acid (KA) resembles the effects induced by the pathological release of glutamate. Lidocaine administered by different routes exerts some neuroprotective effects in the CNS. The aim of the present work was to determine whether lidocaine simultaneously injected with KA into the spinal cord could prevent the excitotoxic effects of the latter. Sprague-Dawley rats were injected by intraparenchymal route with KA or with KA plus 0.5% lidocaine into the C5 segment. Sham rats were injected with saline. Animals were motor and sensory tested at 0, 1, 2, 3, 7 and 14 post-injection days and then euthanized. Sections of the C5 segment were used for histological and immunohistochemical analysis. No KA-induced motor and sensitive impairments were observed when lidocaine was simultaneously injected with KA. Moreover, neuronal counting was statistically higher when compared with KA-injected animals. Thus, lidocaine could be considered as a neuroprotective drug in diseases and models involving excitotoxicity.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
